Kinetics of protein deposition and replacement from a shear flow
Kinetics of plasma protein deposition and replacement from a shear flow of full strength and diluted blood plasma onto prewetted glass were studied both numerically and experimentally. A band of fibrinogen moving down the adsorbing surface was predicted and observed. The band was shown to define the...
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Published in | AIChE journal Vol. 44; no. 2; pp. 233 - 244 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.02.1998
Wiley Subscription Services American Institute of Chemical Engineers |
Subjects | |
Online Access | Get full text |
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Summary: | Kinetics of plasma protein deposition and replacement from a shear flow of full strength and diluted blood plasma onto prewetted glass were studied both numerically and experimentally. A band of fibrinogen moving down the adsorbing surface was predicted and observed. The band was shown to define the region where blood platelets subsequently adhered to the surface. Since platelet adhesion is a fundamental component of thrombosis, this observation is potentially pertinent to the long‐sought mechanism that determines where thrombus forms during shear flow of blood through artificial devices. The discrepancies between the mathematical model and experimental observations are explained by the presence of the natural convection, arising from density differences between plasma and the wetting fluids. |
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Bibliography: | ArticleID:AIC690440202 istex:8B929AA0280A347B642CA024D6335D81BD41E070 ark:/67375/WNG-5LL04KVG-R ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0001-1541 1547-5905 |
DOI: | 10.1002/aic.690440202 |