Potassium Channels and the Atomic Basis of Selective Ion Conduction (Nobel Lecture)

Closing in on the facts: The key to understanding the transport of K+ ions through the cell membrane lay in the structure elucidation of a K+ ion channel (see picture). The studies of Roderick MacKinnon and co‐workers have contributed significantly to the understanding of this research area. In his...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 43; no. 33; pp. 4265 - 4277
Main Author MacKinnon, Roderick
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 20.08.2004
WILEY‐VCH Verlag
Subjects
Bacterial Proteins
ion channels
Ions - metabolism
membranes
Models, Molecular
Nobel Lecture
Potassium Channels - chemistry
Potassium Channels - metabolism
Protein Structure, Quaternary
protein structures
structure elucidation
Substrate Specificity
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Summary:Closing in on the facts: The key to understanding the transport of K+ ions through the cell membrane lay in the structure elucidation of a K+ ion channel (see picture). The studies of Roderick MacKinnon and co‐workers have contributed significantly to the understanding of this research area. In his Nobel Lecture, he describes the structural characteristics of K+ ion channels as well as a possible mechanism for ion conduction.
Bibliography:ark:/67375/WNG-29Q858KG-8
ArticleID:ANIE200400662
istex:1980F9CDF11FF71A3F222E22D0D484DB374A9B6F
Copyright© The Nobel Foundation 2003. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.
ObjectType-Speech/Lecture-1
ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200400662