Fibrinogen Patterns and Activity on Substrates with Tailored Hydroxy Density
The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. The amount of adsorbed FG, quantified by western‐blotting combined with image analysis of the corresponding bands, decreases as the hydrophilici...
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Published in | Macromolecular bioscience Vol. 9; no. 8; pp. 766 - 775 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Weinheim
WILEY-VCH Verlag
11.08.2009
WILEY‐VCH Verlag Wiley-VCH |
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Abstract | The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. The amount of adsorbed FG, quantified by western‐blotting combined with image analysis of the corresponding bands, decreases as the hydrophilicity of the substrate increases. The influence of substrate wettability on FG conformation and distribution is observed by atomic force microscopy (AFM). The most hydrophobic substrate promotes FG fibrillogenesis, which leads to a fibrin‐like appearance in the absence of any thrombin. The degree of FG interconnection was quantified by calculating the fractal dimension of the adsorbed protein from image analysis of the AFM results. The biological activity of the adsorbed FG is correlated to cell adhesion on FG‐coated substrates.
Fibrinogen adsorption on model substrates with controlled OH density is quantified by western‐blotting and its conformation directly observed by AFM. Substrate‐induced fibrinogen fibrillogenesis is enhanced on some substrates as a consequence of protein material interactions, in absence of either any thrombin or cells. The protein conformation is related to initial cell adhesion. |
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AbstractList | The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. The amount of adsorbed FG, quantified by western-blotting combined with image analysis of the corresponding bands, decreases as the hydrophilicity of the substrate increases. The influence of substrate wettability on FG conformation and distribution is observed by atomic force microscopy (AFM). The most hydrophobic substrate promotes FG fibrillogenesis, which leads to a fibrin-like appearance in the absence of any thrombin. The degree of FG interconnection was quantified by calculating the fractal dimension of the adsorbed protein from image analysis of the AFM results. The biological activity of the adsorbed FG is correlated to cell adhesion on FG-coated substrates. The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. The amount of adsorbed FG, quantified by western‐blotting combined with image analysis of the corresponding bands, decreases as the hydrophilicity of the substrate increases. The influence of substrate wettability on FG conformation and distribution is observed by atomic force microscopy (AFM). The most hydrophobic substrate promotes FG fibrillogenesis, which leads to a fibrin‐like appearance in the absence of any thrombin. The degree of FG interconnection was quantified by calculating the fractal dimension of the adsorbed protein from image analysis of the AFM results. The biological activity of the adsorbed FG is correlated to cell adhesion on FG‐coated substrates. Fibrinogen adsorption on model substrates with controlled OH density is quantified by western‐blotting and its conformation directly observed by AFM. Substrate‐induced fibrinogen fibrillogenesis is enhanced on some substrates as a consequence of protein material interactions, in absence of either any thrombin or cells. The protein conformation is related to initial cell adhesion. Abstract The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. The amount of adsorbed FG, quantified by western‐blotting combined with image analysis of the corresponding bands, decreases as the hydrophilicity of the substrate increases. The influence of substrate wettability on FG conformation and distribution is observed by atomic force microscopy (AFM). The most hydrophobic substrate promotes FG fibrillogenesis, which leads to a fibrin‐like appearance in the absence of any thrombin. The degree of FG interconnection was quantified by calculating the fractal dimension of the adsorbed protein from image analysis of the AFM results. The biological activity of the adsorbed FG is correlated to cell adhesion on FG‐coated substrates. magnified image |
Author | Monleón Pradas, Manuel Moratal, David Salmerón-Sánchez, Manuel Rodríguez Hernández, José Carlos Rico, Patricia |
Author_xml | – sequence: 1 givenname: José Carlos surname: Rodríguez Hernández fullname: Rodríguez Hernández, José Carlos organization: Center for Biomaterials and Tissue Engineering, Universidad Politécnica de Valencia, 46022 Valencia, Spain – sequence: 2 givenname: Patricia surname: Rico fullname: Rico, Patricia organization: Center for Biomaterials and Tissue Engineering, Universidad Politécnica de Valencia, 46022 Valencia, Spain – sequence: 3 givenname: David surname: Moratal fullname: Moratal, David organization: Center for Biomaterials and Tissue Engineering, Universidad Politécnica de Valencia, 46022 Valencia, Spain – sequence: 4 givenname: Manuel surname: Monleón Pradas fullname: Monleón Pradas, Manuel organization: Center for Biomaterials and Tissue Engineering, Universidad Politécnica de Valencia, 46022 Valencia, Spain – sequence: 5 givenname: Manuel surname: Salmerón-Sánchez fullname: Salmerón-Sánchez, Manuel email: masalsan@fis.upv.es organization: Center for Biomaterials and Tissue Engineering, Universidad Politécnica de Valencia, 46022 Valencia, Spain |
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Keywords | Liquid solid adsorption Adsorption capacity Experimental study Protein Biological activity Colloidal gel Wettability Cell adhesion Adsorbed state Fibrinogen Surface properties Ethyl acrylate copolymer Hydroxyethyl acrylate copolymer Fibroblast Conformation |
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Snippet | The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. The... Abstract The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy... |
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SubjectTerms | 3T3 Cells Acrylates - chemistry Adsorption Animals Applied sciences Atomic force microscopy Biocompatible Materials Biological and medical sciences Biomimetic Materials - chemistry Cell Adhesion cell-material interaction Density Exact sciences and technology Fibrinogen Fibrinogen - chemistry Fractal analysis Fundamental and applied biological sciences. Psychology Hydrophobic and Hydrophilic Interactions Image analysis Mice Microscopy, Atomic Force Molecular biophysics Organic polymers Physicochemistry of polymers Polymers - chemistry Properties and characterization proteins Solution and gel properties Surface chemistry Surface Properties Surface properties. Adsorption Thrombin Wettability |
Title | Fibrinogen Patterns and Activity on Substrates with Tailored Hydroxy Density |
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