Recent development trends for chiral stationary phases based on chitosan derivatives, cyclofructan derivatives and chiral porous materials in high performance liquid chromatography

The separation of enantiomers by chromatographic methods, such as gas chromatography, high‐performance liquid chromatography and capillary electrochromatography, has become an increasingly significant challenge over the past few decades due to the demand of pharmaceutical, agrochemical, and food ana...

Full description

Saved in:
Bibliographic Details
Published inJournal of separation science Vol. 42; no. 1; pp. 6 - 20
Main Authors Xie, Sheng‐Ming, Yuan, Li‐Ming
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.01.2019
Subjects
chiral recognition
chiral stationary phases
Chitosan
Chitosan - chemistry
Chitosan - isolation & purification
Chromatography
Chromatography, High Pressure Liquid
Derivatives
Electrochromatography
Enantiomers
enantioseparation
Fructans - chemistry
Fructans - isolation & purification
Gas chromatography
High performance liquid chromatography
Metal-Organic Frameworks - chemistry
Metal-Organic Frameworks - isolation & purification
Optical activity
Particle Size
Phases
Porosity
Porous materials
Selectors
Separation
Stereoisomerism
Surface Properties
Trends
enantioseparation
high-performance liquid chromatography
chiral recognition
chiral stationary phases
Online AccessGet full text

Cover

More Information
Summary:The separation of enantiomers by chromatographic methods, such as gas chromatography, high‐performance liquid chromatography and capillary electrochromatography, has become an increasingly significant challenge over the past few decades due to the demand of pharmaceutical, agrochemical, and food analysis. Among these chromatographic resolution methods, high‐performance liquid chromatography based on chiral stationary phases has become the most popular and effective method used for the analytical and preparative separation of optically active compounds. This review mainly focuses on the recent development trends for novel chiral stationary phases based on chitosan derivatives, cyclofructan derivatives, and chiral porous materials that include metal‐organic frameworks and covalent organic frameworks in high‐performance liquid chromatography. The enantioseparation performance and chiral recognition mechanisms of these newly developed chiral selectors toward enantiomers are discussed in detail.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.201800656