A bilateral clinical model for the study of acute and chronic pain after breast-reduction surgery
Background: There is a need for new clinical models to investigate effectively the development of pain after surgery and the effect, if any, of pre‐emptive treatment. Bilateral models are of special interest, since the patient serves as his/her own control. The objective of this preliminary study wa...
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Published in | Acta anaesthesiologica Scandinavica Vol. 45; no. 5; pp. 576 - 582 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Copenhagen
Munksgaard International Publishers
01.05.2001
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Background: There is a need for new clinical models to investigate effectively the development of pain after surgery and the effect, if any, of pre‐emptive treatment. Bilateral models are of special interest, since the patient serves as his/her own control. The objective of this preliminary study was to test a clinical model for the study of acute and chronic pain after bilateral reduction mammoplasty.
Methods: Eight patients participated in the study where the breasts were randomized to test and control groups. In each patient, one breast was preoperatively infiltrated with lidocaine and adrenaline and the other breast infiltrated with saline and adrenaline. Assessment included visual analogue scale (VAS) pain intensity, thermal thresholds, mapping for punctate hyperalgesia and tactile sensation. Assessments were made preoperatively, postoperatively and at 6 months after surgery.
Results: With regard to acute postoperative pain intensity, the model demonstrated a clear difference between lidocaine and placebo treated breasts. There was no difference between lidocaine and placebo treated breasts with regard to chronic pain, but these results are inconclusive due to small number of patients.
Conclusion: The model is sensitive and may be useful in studies of mechanisms of development and prevention of chronic pain after surgery. |
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Bibliography: | ark:/67375/WNG-GT88GBK2-H ArticleID:aas0o122 istex:7BFC11BF8D162887D8FB1F3A1C77856CFAEFD7B7 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23 |
ISSN: | 0001-5172 1399-6576 |
DOI: | 10.1034/j.1399-6576.2001.045005576.x |