Prognostic Value of Biochemical Response to Neoadjuvant Androgen Deprivation before External Beam Radiotherapy for Prostate Cancer: A Systematic Review of the Literature
Highlights • In patients with intermediate- or high-risk localized prostate cancer treated with curative radiotherapy biochemical response to neoadjuvant androgen deprivation represents a strong predictor of improved outcome. • PSA decline during the first months of androgen blockade may represent a...
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Published in | Cancer treatment reviews Vol. 46; pp. 35 - 41 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
01.05.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • In patients with intermediate- or high-risk localized prostate cancer treated with curative radiotherapy biochemical response to neoadjuvant androgen deprivation represents a strong predictor of improved outcome. • PSA decline during the first months of androgen blockade may represent a simple and robust surrogate marker of the intrinsic androgen sensitivity of tumor cells. • A therapeutic gain would be possible by individualizing treatment strategies based on the PSA response after neoadjuvant androgen deprivation. |
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Bibliography: | SourceType-Scholarly Journals-1 ObjectType-Feature-4 ObjectType-Undefined-1 content type line 23 ObjectType-Review-2 ObjectType-Article-3 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0305-7372 1532-1967 |
DOI: | 10.1016/j.ctrv.2016.03.016 |