Biodegradable liposome-encapsulated hydrogels for biomedical applications: a marriage of convenience

Hydrogels are hydrophilic three-dimensional networks with demonstrated potential for medical and pharmaceutical applications. Specifically, biopolymer-based hydrogels offer certain advantages over synthetic polymers in terms of biocompatibility and biodegradability. Because of their inherent propert...

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Published inBiomaterials science Vol. 4; no. 4; pp. 555 - 574
Main Authors Grijalvo, Santiago, Mayr, Judith, Eritja, Ramon, Díaz, David Díaz
Format Journal Article
LanguageEnglish
Published England 01.04.2016
Subjects
antibodies
Biocompatibility
Biodegradability
Biomedical materials
Biopolymers - chemistry
Drug Delivery Systems - methods
drugs
Encapsulation
Humans
Hydrogels
Hydrogels - chemistry
hydrophilicity
Hydrophobic and Hydrophilic Interactions
hydrophobicity
Liposomes
Liposomes - chemistry
Liposomes - metabolism
niosomes
nucleic acids
Nucleic Acids - chemistry
Nucleic Acids - metabolism
polymers
proteins
Proteins - chemistry
Proteins - metabolism
Strategy
therapeutics
Three dimensional
tissue engineering
Tissue Engineering - methods
toxicity
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Summary:Hydrogels are hydrophilic three-dimensional networks with demonstrated potential for medical and pharmaceutical applications. Specifically, biopolymer-based hydrogels offer certain advantages over synthetic polymers in terms of biocompatibility and biodegradability. Because of their inherent properties, hydrogels are able to efficiently encapsulate and liberate in a controlled release manner, different hydrophobic and hydrophilic therapeutic molecules, including nucleic acids, proteins and antibodies. Several strategies have been reported in the literature to minimize the potential burst release of encapsulated drugs, thus preventing their local accumulation and consequent toxic responses. Within this context, liposomes embedded in hydrogels have emerged as an attractive strategy to reduce this undesirable effect. This tutorial review covers a selection of the most promising cationic, neutral and anionic biopolymer-based hydrogels containing liposomes, niosomes or vesicles for drug delivery or tissue engineering applications. Liposome-encapsulated hydrogels have emerged as an attractive strategy for medical and pharmaceutical applications.
Bibliography:Santiago Grijalvo was born and grew up in Madrid. In 2000, he received his Bachelor's degree in Chemistry (with an emphasis in Organic Chemistry) from the Autonomous University of Madrid. After finishing his studies, he was hired as an intern at GlaxoSmithKline for one year. In 2002 he moved to Barcelona to join Dr Antonio Delgado's research group to do his PhD studies focusing on the synthesis of modified sphingolipids combinatorial libraries at the Institute of Research Chemistry (IIQAB-CSIC). In 2007 he joined Prof. Dr Ramon Eritja's research group as a post-doctoral researcher at the Institute of Advanced Chemistry (IQAC). Since then, he has participated in several research projects focusing on improving the cellular uptake of nucleic acids using either covalent or electrostatic strategies.
Ramon Eritja studied Chemistry and Pharmacy at the University of Barcelona, receiving his Ph.D. from the University of Barcelona in 1983. He did postdoctoral work in Dr Itakura's and Caruthers's groups. In 1990, he became group leader at CSIC and then at EMBL. He returned in 1999 to IQAC-CSIC and in 2012 he was appointed director of the institute (IQAC). He is a member of the CIBER-BBN network since 2006. His research focuses on oligonucleotide synthesis for biomedical and nanotechnological applications.
Judith Mayr studied Chemistry at the University of Regensburg, receiving her Bachelor′s degree in 2011 and her Master degree in 2013, respectively. Currently she is doing her PhD in the group of Prof. Díaz Díaz. Her main research interest lies in the use of soft material for the formulation and delivery of therapeutically active molecules.
David Díaz Díaz (born in 1974, Tenerife) received his PhD in Chemistry at the University of La Laguna. In 2002, he joined Prof. Finn's group as postdoc at The Scripps Research Institute (San Diego, USA). Since 2006, he has held various positions in academia and industry ('Ramón y Cajal' Researcher, Autonomous University of Madrid, Spain, 2006; Sr. Chemist, The Dow Chemical Company, Switzerland, 2007; Tenured Scientist, CSIC, Spain, 2009; Alexander von Humboldt Experienced Researcher, University of Regensburg, Germany, 2010). In 2013, he was named recipient of the DFG Heisenberg Professorship. He has received the Young Investigator Award from the Polymer Network Group (Japan, 2014) and he is Editor-in-Chief of Gels. His main research interest focuses on the development of advanced functional soft materials.
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ISSN:2047-4830
2047-4849
2047-4849
DOI:10.1039/c5bm00481k