Strategies for Cartilage Repair in Osteoarthritis Based on Diverse Mesenchymal Stem Cells‐Derived Extracellular Vesicles

Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often manifested by excessive chondrocyte death, inflammatory response, abnormal bone metabolism, imbalance of extracellular matrix (ECM) metaboli...

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Published inOrthopaedic surgery Vol. 15; no. 11; pp. 2749 - 2765
Main Authors Huang, Shanjun, Liu, Yujiao, Wang, Chenglong, Xiang, Wei, Wang, Nianwu, Peng, Li, Jiang, Xuanang, Zhang, Xiaomin, Fu, Zhijiang
Format Journal Article
LanguageEnglish
Published Beijing John Wiley & Sons, Inc 01.11.2023
John Wiley & Sons Australia, Ltd
Wiley
Subjects
Apoptosis
Arthritis
Autophagy
Cartilage
Cartilage repair
Cell cycle
Chondrocytes
Extracellular matrix
Extracellular vesicles
Hyaluronic acid
Inflammation
Mesenchymal stem cells
Metabolism
Osteoarthritis
Physiology
Proteins
Review
Stem cells
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Abstract Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often manifested by excessive chondrocyte death, inflammatory response, abnormal bone metabolism, imbalance of extracellular matrix (ECM) metabolism, and abnormal vascular or nerve growth. Regrettably, due to the avascular nature of cartilage, its capacity to repair is notably limited. Mesenchymal stem cells‐derived extracellular vesicles (MSCs‐EVs) play a pivotal role in intercellular communication, presenting promising potential not only as early diagnostic biomarkers in OA but also as efficacious therapeutic strategy. MSCs‐EVs were confirmed to play a therapeutic role in the pathological process of cartilage injury mentioned above. This paper comprehensively provides the functions and mechanisms of MSCs‐EVs in cartilage repair.
AbstractList Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often manifested by excessive chondrocyte death, inflammatory response, abnormal bone metabolism, imbalance of extracellular matrix (ECM) metabolism, and abnormal vascular or nerve growth. Regrettably, due to the avascular nature of cartilage, its capacity to repair is notably limited. Mesenchymal stem cells‐derived extracellular vesicles (MSCs‐EVs) play a pivotal role in intercellular communication, presenting promising potential not only as early diagnostic biomarkers in OA but also as efficacious therapeutic strategy. MSCs‐EVs were confirmed to play a therapeutic role in the pathological process of cartilage injury mentioned above. This paper comprehensively provides the functions and mechanisms of MSCs‐EVs in cartilage repair.
Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often manifested by excessive chondrocyte death, inflammatory response, abnormal bone metabolism, imbalance of extracellular matrix (ECM) metabolism, and abnormal vascular or nerve growth. Regrettably, due to the avascular nature of cartilage, its capacity to repair is notably limited. Mesenchymal stem cells‐derived extracellular vesicles (MSCs‐EVs) play a pivotal role in intercellular communication, presenting promising potential not only as early diagnostic biomarkers in OA but also as efficacious therapeutic strategy. MSCs‐EVs were confirmed to play a therapeutic role in the pathological process of cartilage injury mentioned above. This paper comprehensively provides the functions and mechanisms of MSCs‐EVs in cartilage repair. We summarized the functions and mechanisms of extracellular vesicles in cartilage repair (including protecting excessive chondrocyte death, regulating the generation of osteoblasts and osteoclasts, balancing extracellular matrix metabolism, alleviating inflammatory response, regulating angiogenesis, etc.) and presented our views, which confirmed that exosomes are potential strategies for cartilage repair.
Author Xiang, Wei
Huang, Shanjun
Wang, Nianwu
Wang, Chenglong
Peng, Li
Jiang, Xuanang
Fu, Zhijiang
Zhang, Xiaomin
Liu, Yujiao
AuthorAffiliation 1 Orthopedics Department The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China
AuthorAffiliation_xml – name: 1 Orthopedics Department The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China
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  givenname: Shanjun
  orcidid: 0009-0005-7817-6967
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  givenname: Yujiao
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  givenname: Chenglong
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  organization: Orthopedics Department The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China
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  surname: Peng
  fullname: Peng, Li
  organization: Orthopedics Department The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China
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  surname: Jiang
  fullname: Jiang, Xuanang
  organization: Orthopedics Department The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China
– sequence: 8
  givenname: Xiaomin
  surname: Zhang
  fullname: Zhang, Xiaomin
  organization: Orthopedics Department The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China
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  surname: Fu
  fullname: Fu, Zhijiang
  organization: Orthopedics Department The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou China
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2023 The Authors. published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.
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Notes Shanjun Huang, Yujiao Liu and Chenglong Wang contributed equally to this work.
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Snippet Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often...
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SubjectTerms Apoptosis
Arthritis
Autophagy
Cartilage
Cartilage repair
Cell cycle
Chondrocytes
Extracellular matrix
Extracellular vesicles
Hyaluronic acid
Inflammation
Mesenchymal stem cells
Metabolism
Osteoarthritis
Physiology
Proteins
Review
Stem cells
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Title Strategies for Cartilage Repair in Osteoarthritis Based on Diverse Mesenchymal Stem Cells‐Derived Extracellular Vesicles
URI https://www.proquest.com/docview/2885370736
https://pubmed.ncbi.nlm.nih.gov/PMC10622303
https://doaj.org/article/8fa4eb8ac26f4c0790b82e626a0cecdf
Volume 15
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