Strategies for Cartilage Repair in Osteoarthritis Based on Diverse Mesenchymal Stem Cells‐Derived Extracellular Vesicles

Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often manifested by excessive chondrocyte death, inflammatory response, abnormal bone metabolism, imbalance of extracellular matrix (ECM) metaboli...

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Published inOrthopaedic surgery Vol. 15; no. 11; pp. 2749 - 2765
Main Authors Huang, Shanjun, Liu, Yujiao, Wang, Chenglong, Xiang, Wei, Wang, Nianwu, Peng, Li, Jiang, Xuanang, Zhang, Xiaomin, Fu, Zhijiang
Format Journal Article
LanguageEnglish
Published Beijing John Wiley & Sons, Inc 01.11.2023
John Wiley & Sons Australia, Ltd
Wiley
Subjects
Apoptosis
Arthritis
Autophagy
Cartilage
Cartilage repair
Cell cycle
Chondrocytes
Extracellular matrix
Extracellular vesicles
Hyaluronic acid
Inflammation
Mesenchymal stem cells
Metabolism
Osteoarthritis
Physiology
Proteins
Review
Stem cells
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Summary:Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often manifested by excessive chondrocyte death, inflammatory response, abnormal bone metabolism, imbalance of extracellular matrix (ECM) metabolism, and abnormal vascular or nerve growth. Regrettably, due to the avascular nature of cartilage, its capacity to repair is notably limited. Mesenchymal stem cells‐derived extracellular vesicles (MSCs‐EVs) play a pivotal role in intercellular communication, presenting promising potential not only as early diagnostic biomarkers in OA but also as efficacious therapeutic strategy. MSCs‐EVs were confirmed to play a therapeutic role in the pathological process of cartilage injury mentioned above. This paper comprehensively provides the functions and mechanisms of MSCs‐EVs in cartilage repair.
Bibliography:Shanjun Huang, Yujiao Liu and Chenglong Wang contributed equally to this work.
ISSN:1757-7853
1757-7861
DOI:10.1111/os.13848