Methylenetetrahydrofolate reductase 677C> T polymorphism and gastric cancer susceptibility in Mexico

• Published in: European journal of cancer (1990) Vol. 42; no. 4; pp. 528 - 533
• Main Authors: Lacasaña-Navarro, Marina, Galván-Portillo, Marcia, Chen, Jia, López-Cervantes, Malaquı́as, López-Carrillo, Lizbeth
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.03.2006; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol Drinking - epidemiology; Biological and medical sciences; Case-control; Female; Folic Acid - administration & dosage; Gastric cancer; Genetic Predisposition to Disease - genetics; Genotype; Humans; Male; Medical sciences; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Mexico; Mexico - epidemiology; Middle Aged; Pharmacology. Drug treatments; Polymorphism; Polymorphism, Genetic - genetics; Risk Factors; Stomach Neoplasms - enzymology; Stomach Neoplasms - epidemiology; Stomach Neoplasms - genetics; Susceptibility; Tumors; Central America; Mexico; America; Mexico; Susceptibility; Gastric cancer; Polymorphism; Case-control; Methylenetetrahydrofolate reductase (NADPH); Genetic variability; Enzyme; Genotype; Pharmacology; Malignant tumor; Stomach cancer; Polymorphism Gastric cancer Susceptibility Case-control Mexico; Cancerology; Digestive diseases; Oxidoreductases; Gastric disease
• ISSN: 0959-8049; 1879-0852
• DOI: 10.1016/j.ejca.2005.10.020

This study investigated whether methylenetetrahydrofolate reductase MTHFR 677C> T polymorphism modified gastric cancer (GC) risk independently as well as in combination with folate intake and alcohol consumption. A hospital-based case-control study of 201 cases and 427 controls was conducted in three geographical areas of Mexico, between 1994 and 1996. The MTHFR 677T allele frequency was 51.0% in cases compared with 45.3% in controls. After controlling for dietary sources of folate, alcohol intake and other selected variables, a significant increase in GC risk was found among carriers of the 677TT genotype compared with those with the 677CC genotype (odds ratio (OR) 1.62, 95% confidence interval (CI) 1.00–2.59), with a significant trend ( P = 0.048). There were no significant interactions between the MTHFR polymorphism and consumption of folate and alcohol. Our results suggest that the high prevalence of MTHFR 677 T allele may be a contributor to the high rate of morbidity and mortality in GC in Mexico.