High-affinity host-guest chemistry of large-ring cyclodextrins

The host-guest chemistry of large-ring cyclodextrins (LRCDs) has been largely unexplored due to the lack of suitable guest molecules that bind with significant affinities to enable potential applications. Herein, we report their complexation with dodecaborate anions (B 12 X 12 2− ), a novel class of...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 14; no. 32; pp. 772 - 776
Main Authors Assaf, Khaleel I, Gabel, Detlef, Zimmermann, Wolfgang, Nau, Werner M
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Anions - chemistry
Boron Compounds - chemistry
Cyclodextrins - chemistry
Online AccessGet full text

Cover

More Information
Summary:The host-guest chemistry of large-ring cyclodextrins (LRCDs) has been largely unexplored due to the lack of suitable guest molecules that bind with significant affinities to enable potential applications. Herein, we report their complexation with dodecaborate anions (B 12 X 12 2− ), a novel class of guest molecules. The binding constants of the inorganic guests (10 4 -10 6 M −1 ) allow their classification as the first tight binders for LRCDs. Unprecedented affinities for large-ring cyclodextrins have been achieved with purely inorganic guest molecules (dodecaborate cluster anions).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c6ob01161f