Polymorphisms in DNA repair and multidrug resistance genes among Sindhis of Central India

• Published in: Environmental toxicology and pharmacology Vol. 40; no. 2; pp. 480 - 485
• Main Authors: Pramanik, Sreemanta, Surendran, Subin T, Arumugam, Sathishkumar, Devi, Saravana, Krishnamurthi, Kannan, Chakrabarti, Tapan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: Adult; ATP Binding Cassette Transporter 1 - genetics; Cancer; DNA Glycosylases - genetics; DNA Repair; DNA-Binding Proteins - genetics; Drug disposition; Emergency; European Continental Ancestry Group - ethnology; European Continental Ancestry Group - genetics; Gene Frequency; Genotype; Humans; India - ethnology; Indian Sindhis; Male; Middle Aged; Multidrug resistance; Phylogeny; Polymorphism, Single Nucleotide; SNP; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein - genetics; Young Adult; India, Maharashtra, Vidarbha; ASW, USA, Texas; USA, Texas, Houston; USA, Utah; India; Indian Sindhis; SNP; Drug disposition; DNA repair; Multidrug resistance; Cancer
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2015.07.019

Highlights • India is one of the most ethnically and genetically diverse regions of the world. • 6 SNPs in DNA repair and multidrug resistance genes were studied in Indian Sindhis. • These SNPs could influence susceptibility to cancer and drug disposition. • We determined the allele and genotype frequencies of these SNPs in Indian Sindhis. • Sindhis were closely related to Maharshtrians and some other HapMap populations.