Physical Exercise and Serum BDNF Levels: Accounting for the Val66Met Polymorphism in Older Adults

• Published in: Cognitive and behavioral neurology Vol. 36; no. 4; p. 219
• Main Authors: Bugge Kambestad, Oda, Sirevåg, Kristine, Mrdalj, Jelena, Hovland, Anders, Bruun Endal, Trygve, Andersson, Eva, Sjøbø, Trond, Haukenes Stavestrand, Silje
• Format: Journal Article
• Language: English
• Published: United States 01.12.2023
• Subjects: Aged; Brain-Derived Neurotrophic Factor - genetics; Exercise; Female; Genotype; Humans; Male; Polymorphism, Genetic - genetics; Polymorphism, Single Nucleotide - genetics; Serum
• ISSN: 1543-3641
• DOI: 10.1097/WNN.0000000000000349

Brain-derived neurotrophic factor (BDNF) expression, which can be measured in blood serum, has been found to increase with aerobic exercise. The link between BDNF level, physical exercise, and genetic status (Val66Met polymorphism) has not been well researched in older adults. To investigate the possible link between BDNF expression, acute aerobic exercise, and the Val66Met polymorphism in older adults. Twenty-three healthy older adults participated in one session of acute aerobic exercise. Their serum BDNF levels were measured both at baseline and post exercise. Saliva samples were collected to identify each individual's genetic status. At baseline, the individuals' mean serum BDNF level was 16.03 ng/mL (Val66Val = 15.89 ng/mL; Val66Met = 16.34 ng/mL); post exercise, the individuals' mean serum BDNF level was 16.81 ng/mL (Val66Val = 16.14 ng/mL; Val66Met = 18.34 ng/mL). One session of acute aerobic exercise significantly increased the individuals' mean serum BDNF level. Males had higher BDNF levels than females. There was a significant interaction between gender and BDNF expression post exercise and a significant between-group effect of gender. The Val66Met carriers had a more positive response to the acute aerobic exercise compared with the Val66Val carriers, although without a significant difference between the two groups.