Malaria parasite egress at a glance

All intracellular pathogens must escape (egress) from the confines of their host cell to disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole or in a cyst, and must undergo egress at four distinct phases during its complex life cycle, each time disrupting, in...

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Bibliographic Details
Published inJournal of cell science Vol. 134; no. 5
Main Authors Tan, Michele S Y, Blackman, Michael J
Format Journal Article
LanguageEnglish
Published England 01.03.2021
Subjects
Animals
Erythrocytes
Life Cycle Stages
Malaria
Parasites
Plasmodium
Plasmodium falciparum
Protozoan Proteins
Plasmodium
Protozoan
Egress
Malaria
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Summary:All intracellular pathogens must escape (egress) from the confines of their host cell to disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole or in a cyst, and must undergo egress at four distinct phases during its complex life cycle, each time disrupting, in a highly regulated manner, the membranes or cyst wall that entrap the parasites. This Cell Science at a Glance article and accompanying poster summarises our current knowledge of the morphological features of egress across the life cycle, the molecular mechanisms that govern the process, and how researchers are working to exploit this knowledge to develop much-needed new approaches to malaria control.
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ISSN:0021-9533
1477-9137
DOI:10.1242/jcs.257345