Overlapping Stevens-Johnson Syndrome and DRESS Syndrome Caused by Phenobarbital: A Vietnamese Case Report

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Stevens-Johnson Syndrome (SJS) are severe cutaneous adverse reactions to drugs. Those reactions which are rare in children can be especially severe and challenging to diagnose and manage. Herein we present a 59-month-old male...

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Published inGlobal pediatric health Vol. 10; p. 2333794X231216556
Main Authors Van Nguyen, Khiem, Van Vu, Quang, Tran, Mai Hoang, Nguyen, Huy Quoc, Le, Chi Quynh, Dang, Bang Cam Thi, Chu, Hieu Chi, Van Nguyen, Dinh
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2023
Sage Publications Ltd
SAGE Publishing
Subjects
Allergies
Case reports
Corticoids
Drug therapy
Side effects
Vietnam
case report
phenobarbital
pediatric patient
Stevens Johnson Syndrome
severe cutaneous adverse reactions
Drug Reaction with Eosinophilia and Systemic Symptoms
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Summary:Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Stevens-Johnson Syndrome (SJS) are severe cutaneous adverse reactions to drugs. Those reactions which are rare in children can be especially severe and challenging to diagnose and manage. Herein we present a 59-month-old male who presented with a rash, fever, and multiple organ dysfunction initiation of Phenobarbital for epilepsy. Diagnosis of ovelaping SJS and DRESS syndrome had been made based on clinical manifestations accompanied with skin biopsy according to RegisSCAR diagnostic criteria. A therapy with intravenous immune globulin (IVIG), corticosteroids and supportive care was given successfully for the patient. This case underscored the significance of promptly and effectively recognizing and managing these intricate reactions.
ISSN:2333-794X
2333-794X
DOI:10.1177/2333794X231216556