Etoricoxib Attenuates Effect of Antihypertensives in a Rodent Model of DOCA-Salt Induced Hypertension

While it is known that non-steroidal anti-inflammatory drugs including selective cyclooxygenase-2 (COX-2) inhibitors influence BP, the exact relationship and underlying mechanisms are still unclear. We investigated the effect of etoricoxib, a selective COX-2 inhibitor on the antihypertensive efficac...

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Bibliographic Details
Published inClinical and experimental hypertension (1993) Vol. 35; no. 8; pp. 601 - 606
Main Authors Chugh, Preeta Kaur, Gupta, Monica, Agarwal, Monika, Tekur, Uma
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.01.2013
Taylor & Francis
Subjects
animal model
Animals
antihypertensive
Antihypertensive Agents - pharmacology
Atenolol - pharmacology
Benzimidazoles - pharmacology
Benzoates - pharmacology
blood pressure
Blood Pressure - drug effects
Cyclooxygenase 2 Inhibitors - pharmacology
cyclooxygenase inhibitors
Desoxycorticosterone Acetate
Disease Models, Animal
hypertension
Hypertension - chemically induced
Hypertension - drug therapy
Mineralocorticoids - poisoning
Pyridines - pharmacology
Ramipril - pharmacology
Rats
Rats, Sprague-Dawley
renin
Sodium Chloride - poisoning
Sulfones - pharmacology
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Summary:While it is known that non-steroidal anti-inflammatory drugs including selective cyclooxygenase-2 (COX-2) inhibitors influence BP, the exact relationship and underlying mechanisms are still unclear. We investigated the effect of etoricoxib, a selective COX-2 inhibitor on the antihypertensive efficacy of atenolol; beta-blocker, ramipril; angiotensin converting enzyme inhibitor and telmisartan; angiotensin receptor blocker in deoxycorticosterone acetate (DOCA)-salt hypertensive rats, a mineralocorticoid volume expansion model. Etoricoxib attenuated the antihypertensive-induced reduction of systolic (atenolol; P < .001, ramipril; P = .011, telmisartan; P = .003) and mean arterial pressure (atenolol; P < .001, ramipril; P = .032, telmisartan; P = .023). These results demonstrate that COX-2 dependent mechanisms play a significant role in blood pressure regulation, and etoricoxib-induced COX-2 inhibition blunts the therapeutic effect of different classes of antihypertensives in this mineralocorticoid volume expansion model of hypertension.
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ISSN:1064-1963
1525-6006
DOI:10.3109/10641963.2013.776567