Peripheral opioidergic regulation of the tracheobronchial mucociliary transport system
Departments of 1 Medicine and 2 Bioengineering University of Illinois at Chicago, and 3 Veterans Affairs Health Care System, West Side, Chicago, Illinois 60612 We hypothesized that, in the airway mucosa, opioids are inhibitory neural modulators that cause an increase in net water absorption in th...
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Published in | Journal of applied physiology (1985) Vol. 94; no. 6; pp. 2375 - 2383 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Am Physiological Soc
01.06.2003
American Physiological Society |
Subjects | |
Online Access | Get full text |
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Summary: | Departments of 1 Medicine and
2 Bioengineering University of Illinois at Chicago,
and 3 Veterans Affairs Health Care System, West
Side, Chicago, Illinois 60612
We hypothesized that, in the airway
mucosa, opioids are inhibitory neural modulators that cause an increase
in net water absorption in the airway mucosa (as in the gut). Changes
in bidirectional water fluxes across ovine tracheal mucosa in response
to basolateral application of the opioid peptides -endorphin,
dynorphin A-(1-8), and
[ D -Ala 2 ,
D -Leu 5 ]-enkephalin (DADLE) were
measured. -Endorphin and dynorphin A-(1-8)
decreased luminal-to-basolateral water fluxes, and dynorphin A-(1-8) and DADLE increased basolateral-to-luminal
water flux. These responses were electroneutral. In seven beagle dogs,
administration of aerosolized -endorphin (1 mg) to the
tracheobronchial airways decreased the clearance of radiotagged
particles from the bronchi in 1 h from 34.7 to 22.0%
( P < 0.001). Naloxone abrogated the -endorphin-induced changes in vitro and in vivo. Contrary to our
hypothesis, the opioid-induced changes in water fluxes would all lead
to a predictable increase in airway surface fluid. The -endorphin-induced increases in airway fluid together with reduced bronchial mucociliary clearance may produce procongestive responses when opioids are administered as antitussives.
inhibitory neural regulation; transepithelial water transport; -endorphin; naloxone |
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ISSN: | 8750-7587 1522-1601 |
DOI: | 10.1152/japplphysiol.00741.2002 |