MoonProt 3.0: an update of the moonlighting proteins database

• Published in: Nucleic Acids Research Vol. 49; no. D1; pp. D368 - D372
• Main Authors: Chen, Chang, Liu, Haipeng, Zabad, Shadi, Rivera, Nina, Rowin, Emily, Hassan, Maheen, Gomez De Jesus, Stephanie M, Llinás Santos, Paola S, Kravchenko, Karyna, Mikhova, Mariia, Ketterer, Sophia, Shen, Annabel, Shen, Sophia, Navas, Erin, Horan, Bryan, Raudsepp, Jaak, Jeffery, Constance
• Format: Journal Article Web Resource
• Language: English
• Published: England Oxford University Press 08.01.2021
• Subjects: Database Issue; Databases, Protein; Humans; Molecular Sequence Annotation; Proteins - chemistry; SARS-CoV-2 - metabolism
• ISSN: 0305-1048; 1362-4962
• DOI: 10.1093/nar/gkaa1101

Abstract MoonProt 3.0 (http://moonlightingproteins.org) is an updated open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins have two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here, we describe an expansion in the database since our previous report in the Database Issue of Nucleic Acids Research in 2018. For this release, the number of proteins annotated has been expanded to over 500 proteins and dozens of protein annotations have been updated with additional information, including more structures in the Protein Data Bank, compared with version 2.0. The new entries include more examples from humans, plants and archaea, more proteins involved in disease and proteins with different combinations of functions. More kinds of information about the proteins and the species in which they have multiple functions has been added, including CATH and SCOP classification of structure, known and predicted disorder, predicted transmembrane helices, type of organism, relationship of the protein to disease, and relationship of organism to cause of disease.