Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

• Published in: Journal of human genetics Vol. 49; no. 11; pp. 629 - 634
• Main Authors: Nawata, Hajime, Shirasawa, Senji, Nakashima, Naoki, Araki, Eiichi, Hashiguchi, Jun, Miyake, Seibei, Yamauchi, Teruaki, Hamaguchi, Kazuyuki, Yoshimatsu, Hironobu, Takeda, Haruo, Fukushima, Hideo, Sasahara, Takayuki, Yamaguchi, Kohei, Sonoda, Noriyuki, Sonoda, Tomoko, Matsumoto, Masahiro, Tanaka, Yoshiya, Sugimoto, Hidekatsu, Tsubouchi, Hirotaka, Inoguchi, Toyoshi, Yanase, Toshihiko, Wake, Nakayasu, Narazaki, Kenziro, Eto, Takashi, Umeda, Fumio, Nakazaki, Mitsuhiro, Ono, Junko, Asano, Takashi, Ito, Yasuko, Akazawa, Shoichi, Hazegawa, Iwaho, Takasu, Nobuyuki, Shinohara, Moritsugu, Nishikawa, Takeshi, Nagafuchi, Seiho, Okeda, Toshimitsu, Eguchi, Katsumi, Iwase, Masanori, Ishikawa, Mayuko, Aoki, Masayuki, Keicho, Naoto, Kato, Norihiro, Yasuda, Kazuki, Yamamoto, Ken, Sasazuki, Takehiko
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.11.2004
• Subjects: Chromosome 11; Chromosomes, Human, Pair 11 - genetics; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Genetic factors; Genetic Linkage; Genetic Predisposition to Disease; Genome, Human; Genomes; Health risk assessment; Humans; Insulin; Insulin secretion; Japan; Linkage analysis; Lod Score; Susceptibility; Japan
• ISSN: 1434-5161; 1435-232X
• DOI: 10.1007/s10038-004-0199-3

Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.