Effect of porous media of the stenosed artery wall to the coronary physiological diagnostic parameter: A computational fluid dynamic analysis

• Published in: Atherosclerosis Vol. 233; no. 2; pp. 630 - 635
• Main Authors: Govindaraju, Kalimuthu, Kamangar, Sarfaraz, Badruddin, Irfan Anjum, Viswanathan, Girish N, Badarudin, A, Salman Ahmed, N.J
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2014
• Subjects: Blood flow; Cardiovascular; Computational fluid dynamics; Computer Simulation; Coronary Circulation; Coronary disease; Coronary Stenosis - diagnosis; Coronary Stenosis - pathology; Coronary Vessels - physiopathology; Coronary Vessels - ultrastructure; FFR; Hemorheology; Humans; Hydrodynamics; Models, Cardiovascular; Permeability; Porosity; Porosity and permeability; Pressure; Stenosis; Vascular Stiffness; Stenosis; Porosity and permeability; FFR; Computational fluid dynamics; Coronary disease; Blood flow
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2014.01.043

Abstract Functional assessment of a coronary artery stenosis severity is generally assessed by fractional flow reserve (FFR), which is calculated from pressure measurements across the stenosis. The purpose of this study is to investigate the effect of porous media of the stenosed arterial wall on this diagnostic parameter. To understand the role of porous media on the diagnostic parameter FFR, a 3D computational simulations of the blood flow in rigid and porous stenotic artery wall models are carried out under steady state and transient conditions for three different percentage area stenoses (AS) corresponding to 70% (moderate), 80% (intermediate), and 90% (severe). Blood was modeled as a non Newtonian fluid. The variations of pressure drop across the stenosis and diagnostic parameter were studied in both models. The FFR decreased in proportion to the increase in the severity of the stenosis. The relationship between the percentage AS and the FFR was non linear and inversely related in both the models. The cut-off value of 0.75 for FFR was observed at 81.89% AS for the rigid artery model whereas 83.61% AS for the porous artery wall model. This study demonstrates that the porous media consideration on the stenotic arterial wall plays a substantial role in defining the cut-off value of FFR. We conclude that the effect of porous media on FFR, could lead to misinterpretation of the functional severity of the stenosis in the region of 81.89 %–83.61% AS.