SerpinC1 /Antithrombin III in kidney-related diseases

The gene encodes a serine protease inhibitor named antithrombin III (ATIII). This protease demonstrates both anticoagulant and anti-inflammatory action. ATIII is the most important coagulation factor inhibitor, and even minor changes in ATIII can significantly alter the risk of thromboembolism. ATII...

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Published inClinical science (1979) Vol. 131; no. 9; pp. 823 - 831
Main Authors Lu, Zeyuan, Wang, Feng, Liang, Mingyu
Format Journal Article
LanguageEnglish
Published England Portland Press Ltd 01.05.2017
Subjects
Antithrombin III - genetics
Antithrombin III - metabolism
Antithrombin III - therapeutic use
Antithrombin III Deficiency - genetics
Antithrombin III Deficiency - metabolism
Blood Coagulation - drug effects
Humans
Inflammation - genetics
Inflammation - metabolism
Inflammation - prevention & control
Kidney Diseases - genetics
Kidney Diseases - metabolism
Models, Biological
Review
Risk Factors
Signal Transduction
Thromboembolism - genetics
Thromboembolism - metabolism
SerpinC1
antithrombin III
kidney injury
hypertension
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Summary:The gene encodes a serine protease inhibitor named antithrombin III (ATIII). This protease demonstrates both anticoagulant and anti-inflammatory action. ATIII is the most important coagulation factor inhibitor, and even minor changes in ATIII can significantly alter the risk of thromboembolism. ATIII can also suppress inflammation via a coagulation-dependent or -independent effect. Moreover, apart from ATIII deficiency, ATIII and its gene may also be related to many diseases (e.g. hypertension, kidney diseases). The present review summarizes how ATIII affects the progress of kidney disease and its mechanism. Further studies are required to investigate how ATIII affects renal function and the treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0143-5221
1470-8736
DOI:10.1042/cs20160669