Betaine treatment decreased oxidative stress, inflammation, and stellate cell activation in rats with alcoholic liver fibrosis

• Published in: Environmental toxicology and pharmacology Vol. 45; pp. 170 - 178
• Main Authors: Bingül, İlknur, Başaran-Küçükgergin, Canan, Aydın, A.Fatih, Çoban, Jale, Doğan-Ekici, Işın, Doğru-Abbasoğlu, Semra, Uysal, Müjdat
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2016
• Subjects: Alcoholic liver fibrosis; Animals; Antioxidants - metabolism; Betaine; Betaine - administration & dosage; Betaine - therapeutic use; Biomarkers - blood; Body Weight - drug effects; Emergency; Female; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - immunology; Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Lipid Peroxidation - drug effects; Liver - drug effects; Liver - immunology; Liver - metabolism; Liver - pathology; Liver Cirrhosis, Alcoholic - immunology; Liver Cirrhosis, Alcoholic - metabolism; Liver Cirrhosis, Alcoholic - pathology; Liver Cirrhosis, Alcoholic - prevention & control; Liver Cirrhosis, Experimental - immunology; Liver Cirrhosis, Experimental - metabolism; Liver Cirrhosis, Experimental - pathology; Liver Cirrhosis, Experimental - prevention & control; Liver Function Tests; Organ Size - drug effects; Oxidative stress; Oxidative Stress - drug effects; Rat; Rats, Sprague-Dawley; Stellate cell activation; alcoholic liver fibrosis; stellate cell activation; rat; betaine; oxidative stress; Alcoholic liver fibrosis; Oxidative stress; Stellate cell activation; Rat; Betaine
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2016.05.033

Highlights • Alcoholic liver fibrosis was induced by ethanol and carbon tetrachloride in rats. • Effect of betaine (BET) on alcoholic liver fibrosis was investigated. • BET supressed oxidative stress, inflammation and hepatic stellate cell activation.