Canine model of nasal congestion and allergic rhinitis

• Published in: Journal of applied physiology (1985) Vol. 94; no. 5; pp. 1821 - 1828
• Main Authors: Tiniakov, Ruslan L, Tiniakova, Olga P, McLeod, Robbie L, Hey, John A, Yeates, Donovan B
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.05.2003; American Physiological Society
• Subjects: Aerosols; Airway Resistance - physiology; Allergic diseases; Allergies; Ambrosia - immunology; Animals; Biological and medical sciences; Disease Models, Animal; Dogs; Drug therapy; Female; Heart Rate - physiology; Histamine; Histamine - pharmacology; Immunopathology; Male; Medical sciences; Nasal Decongestants - therapeutic use; Nasal Obstruction - drug therapy; Nasal Obstruction - physiopathology; Pollen - immunology; Respiratory and ent allergic diseases; Respiratory Mechanics - physiology; Respiratory system; Rhinitis, Allergic, Seasonal - drug therapy; Rhinitis, Allergic, Seasonal - physiopathology; Rhinomanometry; Fissipedia; Immunopathology; Allergy; Animal model; Rhinomanometry; Carnivora; Nose disease; Agonist; Rhinitis; acoustic rhinometry; ragweed; Acoustic method; Histamine; Vertebrata; Mammalia; α-Adrenergic receptor; Animal; α-adrenergic agonist; ENT disease; nasal resistance; Dog
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00930.2002

1  University of Illinois at Chicago, and Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612; and 2  Schering-Plough Research Institute, Kenilworth, New Jersey 07033 The ragweed- and histamine-induced decreases in nasal patency in cohorts of ragweed-sensitized and nonsensitized dogs were assessed. The volume of nasal airways (V NA ) was assessed by acoustic rhinometry and resistance to airflow (R NA ) by anterior rhinomanometry. Histamine delivered to the nasal passages of five dogs caused a rapid and prolonged increase in R NA (0.75 ± 0.26 to 3.56 ± 0.50   cmH 2 O · l 1 · min), an effect that was reversed by intranasal delivery of aerosolized phenylephrine. Ragweed challenge in five ragweed-sensitized dogs increased R NA from 0.16 ± 0.02 to 0.53 ± 0.07 cmH 2 O · l 1 · min and decreased V NA from 12.5 ± 1.9 to 3.9 ± 0.3 cm 3 , whereas administration of saline aerosol neither increased R NA nor decreased V NA . Prior administration of D -pseudoephedrine (30   mg po) attenuated the ragweed-induced increase in R NA and decrease in V NA . Ragweed challenge changed neither R NA nor V NA in four nonsensitized dogs. Mediator-induced nasal congestion and allergen-induced allergic rhinitis in ragweed-sensitized dogs, which exhibit symptoms similar to human disease, can be used in the evaluation of safety and efficacy of antiallergic activity of potential drugs. ragweed; histamine; -adrenergic agonist; nasal resistance; acoustic rhinometry