Kelubi Fruit (Eleiodoxa conferta) extract as a Green Catalyst Synthesis of 3,4-dihydropyrimidin-2 (1H)-ones

The use of synthetic strong acid catalysts or lewis acid catalysts from metals often causes environmental problems at the end of a chemical reaction. In this research offers an alternative solution using kelubi fruit extract (Eleiodoxa conferta) as a green catalyst, especially in the synthesis of 3,...

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Published inIOP conference series. Earth and environmental science Vol. 599; no. 1; pp. 12070 - 12076
Main Authors Mahardika, R G, Sari, R P, Nazrun, Roanisca, O, Abdussalam, M
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.11.2020
Subjects
Benzaldehyde
Catalysts
Chemical reactions
Chemical synthesis
Fruits
Lewis acid
Metals
Reaction time
Reagents
Urea
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Summary:The use of synthetic strong acid catalysts or lewis acid catalysts from metals often causes environmental problems at the end of a chemical reaction. In this research offers an alternative solution using kelubi fruit extract (Eleiodoxa conferta) as a green catalyst, especially in the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones derivatives which are reported to be active as therapeutic and bioorganic chemistry. So the purpose of this research was to develop a green catalyst from natural fruit for the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones using kelubi fruit. The Green catalysts are obtained from water extracts of kelubi fruit that are ripe. Then the catalyst is added to the reagent for the synthesis of pyrimidine derivatives that consist of urea, benzaldehyde, and ethyl acetoacetate (equivalent). As a comparison, HCl is used as an acid catalyst. The result is the highest yield (67,7%) at the use of 0,2 ml green catalyst and reaction time 180 minutes. Spectrum UV-Vis of characteristics compound has a maximum wavelength of 306 nm.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/599/1/012070