Capturing condensin in chromosomes

A new study uses a Hi-C technique to demonstrate that condensin has a major role in remodeling interphase chromatin into mitotic chromosomes. This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome.

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Bibliographic Details
Published inNature genetics Vol. 49; no. 10; pp. 1419 - 1420
Main Author Hirano, Tatsuya
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.10.2017
Subjects
Adenosine Triphosphatases - genetics
Cell cycle
Cell division
Cellular proteins
Chromosomes
Condensin
Cooperation
Deoxyribonucleic acid
DNA
DNA-Binding Proteins - genetics
Genetic aspects
Mitosis
Multiprotein Complexes - genetics
Properties
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Studies
Yeast
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Summary:A new study uses a Hi-C technique to demonstrate that condensin has a major role in remodeling interphase chromatin into mitotic chromosomes. This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome.
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ISSN:1061-4036
1546-1718
DOI:10.1038/ng.3962