Susceptibility to oxidation of copper-induced plasma lipoproteins from Japanese eel: protective effect of vitellogenin on the oxidation of very low density lipoprotein

• Published in: Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Vol. 123; no. 1; pp. 1 - 7
• Main Authors: Ando, Seiichi, Yanagida, Kenji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.1999
• Subjects: Anguilla - blood; Anguilla japonica; Animals; Antioxidant activity; Antioxidants - pharmacology; Brackish; Copper - pharmacology; Copper-induced oxidation; Estradiol - pharmacology; Freshwater; Japanese eel; Lipoproteins, VLDL - blood; Lipoproteins, VLDL - drug effects; Marine; Oxidation-Reduction; Plasma lipoproteins; Thiobarbituric Acid Reactive Substances - metabolism; Thiobarbituric acid-reactive substances; Vitellogenin; Vitellogenins - pharmacology; Japanese eel; Thiobarbituric acid-reactive substances; Plasma lipoproteins; Vitellogenin; Antioxidant activity; Copper-induced oxidation
• ISSN: 0742-8413; 1367-8280
• DOI: 10.1016/S0742-8413(98)10137-8

The susceptibility to oxidation of copper-induced plasma lipoproteins from Japanese eel Anguilla japonica was examined with the guidance of thiobarbituric acid-reactive substances (TBARS). The TBARS values of copper-induced plasma lipoproteins increased with increasing the lipid-to-apolipoprotein ratios and very low density lipoprotein (VLDL) exhibited the highest TBARS value. On the other hand, vitellogenin, estrogen-induced precursor of egg yolk proteins, was resistant to copper-induced oxidation and seemed to chelate low concentrations of copper ion. Vitellogenin also protected the copper-induced oxidation of VLDL because of its antioxidant function. Vitellogenin seemed to serve as transition metals-binding lipoprotein by which free-radical reactions in the oocytes were extensively depressed.