The nuclear pore complex--structure and function at a glance

Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. They are aqueous channels generated from a complex network of evolutionari...

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Bibliographic Details
Published inJournal of cell science Vol. 128; no. 3; pp. 423 - 429
Main Authors Kabachinski, Greg, Schwartz, Thomas U
Format Journal Article
LanguageEnglish
Published England The Company of Biologists 01.02.2015
Subjects
Active Transport, Cell Nucleus - physiology
Cell Line, Tumor
Cell Science at a Glance
Cytoplasm - metabolism
HeLa Cells
Humans
Nuclear Pore - metabolism
Nuclear Pore Complex Proteins - metabolism
RNA - metabolism
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Summary:Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins. In this Cell Science at a Glance article and the accompanying poster, we discuss how transport between the nucleoplasm and the cytoplasm is regulated, what we currently know about the structure of individual nucleoporins and the assembled NPC, and how the cell regulates assembly and disassembly of such a massive structure. Our aim is to provide a general overview on what we currently know about the nuclear pore and point out directions of research this area is heading to.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0021-9533
1477-9137
DOI:10.1242/jcs.083246