Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Traditional treatments such as chemotherapy and surgery usually cause severe side effects and excruciating pain. The emergence of nanomedicines and minimally invasive therapies (MITs) has brought hope to patients with malignant diseases. Especially, minimally invasive nanomedicines (MINs), which com...

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Published inChemical Society reviews Vol. 51; no. 12; pp. 4996 - 541
Main Authors Ouyang, Jiang, Xie, Angel, Zhou, Jun, Liu, Runcong, Wang, Liqiang, Liu, Haijun, Kong, Na, Tao, Wei
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 20.06.2022
Subjects
Bioavailability
Bioengineering
Infectious diseases
Interdisciplinary subjects
Magnetism
Materials science
Medical imaging
Medical research
Nanotechnology
Organs
Pharmacology
Radiation
Side effects
Tissue engineering
Ultrasonic imaging
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Summary:Traditional treatments such as chemotherapy and surgery usually cause severe side effects and excruciating pain. The emergence of nanomedicines and minimally invasive therapies (MITs) has brought hope to patients with malignant diseases. Especially, minimally invasive nanomedicines (MINs), which combine the advantages of nanomedicines and MITs, can effectively target pathological cells/tissues/organs to improve the bioavailability of drugs, minimize side effects and achieve painless treatment with a small incision or no incision, thereby acquiring good therapeutic effects. In this review, we provide a comprehensive review of the research status and challenges of MINs, which generally refers to the medical applications of nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging. Additionally, we also discuss their combined application in various fields including cancers, cardiovascular diseases, tissue engineering, neuro-functional diseases, and infectious diseases. The prospects, and potential bench-to-bedside translation of MINs are also presented in this review. We expect that this review can inspire the broad interest for a wide range of readers working in the fields of interdisciplinary subjects including (but not limited to) chemistry, nanomedicine, bioengineering, nanotechnology, materials science, pharmacology, and biomedicine. This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.
Bibliography:Dr Jiang Ouyang obtained his BS Degree from Huazhong Agricultural University (2013) and his PhD Degree at Central South University (2020). Before graduation, he had one year of training as a joint PhD student in the Center for Nanomedicine at Brigham and Women's Hospital, Harvard Medical School under the supervision of Prof. Wei Tao. His research is focused on the development of various multi-function nanomaterials for different biomedical applications including cancer therapy and sterilization. He is also interested in functional hydrogels and fluorescent probes. Currently, he is a Research Fellow at Jinan University.
Prof. Wei Tao is a Farokhzad Family Distinguished Chair for Innovation and a Principal Investigator in the Center for Nanomedicine, and a Faculty Member in the Department of Anesthesiology, Perioperative, and Pain Medicine at Brigham and Women's Hospital, Harvard Medical School. He is also the first Chaired Professor who is an Assistant Professor in the history of his institution. His research interests include biomaterials, nanotechnology and drug delivery, and their various applications in translational medicine.
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ISSN:0306-0012
1460-4744
DOI:10.1039/d1cs01148k