Beta-adrenoceptors in kidney tubules of spontaneously hypertensive and normotensive rats

Beta-adrenoceptor binding characteristics were determined in different fractions of rat kidney tubules using a [125Iodo]-(-)-cyanopindolol (ICYP) binding assay. The highest amount of binding sites was found in a fraction containing predominantly distal tubular fragments. In a separate series of expe...

Full description

Saved in:
Bibliographic Details
Published inLife sciences (1973) Vol. 38; no. 2; p. 137
Main Authors Struyker-Boudier, H A, Vervoort-Peters, L H, Rousch, M J, Smits, J F, Thijssen, H H
Format Journal Article
LanguageEnglish
Published Netherlands 13.01.1986
Subjects
Animals
Hypertension - metabolism
In Vitro Techniques
Iodocyanopindolol
Kidney Tubules - analysis
Kidney Tubules - drug effects
Kidney Tubules - metabolism
Male
Pindolol - analogs & derivatives
Pindolol - metabolism
Propranolol - pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Adrenergic, beta - analysis
Sodium - metabolism
Online AccessGet more information

Cover

More Information
Summary:Beta-adrenoceptor binding characteristics were determined in different fractions of rat kidney tubules using a [125Iodo]-(-)-cyanopindolol (ICYP) binding assay. The highest amount of binding sites was found in a fraction containing predominantly distal tubular fragments. In a separate series of experiments the ICYP binding characteristics were compared in whole tubular fractions from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) of different ages. The maximum number of binding sites was significantly higher both in young (3 weeks) and adult (14 weeks) SHR when compared to age-matched WKY. These studies showed the presence of beta-adrenoceptor binding sites in rat kidney tubules and support the potential importance of tubular beta-adrenoceptors in the development of spontaneous hypertension and in the mechanism of antihypertensive action of beta-blockers.
ISSN:0024-3205
DOI:10.1016/0024-3205(86)90005-6