Emerging approaches to target tumor metabolism

Highlights • Several tumor oncogenes and suppressors regulate cellular metabolism. • Targeting the metabolic pathways downstream of cancer genes may provide new therapeutic opportunities. • Describe progress in developing inhibitors to tumor-associated metabolic pathways. • Describe emerging targeti...

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Bibliographic Details
Published inCurrent opinion in pharmacology Vol. 17; pp. 22 - 29
Main Authors Ross, Sarah J, Critchlow, Susan E
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2014
Subjects
Animals
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Drug Design
Energy Metabolism - drug effects
Energy Metabolism - genetics
Humans
Internal Medicine
Medical Education
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Signal Transduction - drug effects
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Summary:Highlights • Several tumor oncogenes and suppressors regulate cellular metabolism. • Targeting the metabolic pathways downstream of cancer genes may provide new therapeutic opportunities. • Describe progress in developing inhibitors to tumor-associated metabolic pathways. • Describe emerging targeting strategies for ‘undruggable’ targets.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
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ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2014.07.001