Asymmetric Ventricular Hypertrophy in Patients with Essential Hypertension

We attempted to clarify the pathogenesis of asymmetric ventricular hypertrophy in hypertensive patients, especially regarding sympathetic nervous system and renin-angiotensin system. Subjects were divided in 3 groups by echocardiographic findings; 1) 15 patients with non-hypertrophy (NH), 2) 14 pati...

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Bibliographic Details
Published inJapanese Heart Journal Vol. 23; no. 2; pp. 181 - 190
Main Authors NOMURA, Gakuji, KUMAGAI, Eiichiro, MIDORIKAWA, Keiichi, KITANO, Takaaki, TASHIRO, Hiromi, KOGA, Yoshinori, TOSHIMA, Hironori
Format Journal Article
LanguageEnglish
Published Japan International Heart Journal Association 01.01.1982
Subjects
Adult
Asymmetric ventricular hypertrophy
Blood Pressure
Cardiomegaly - etiology
Cardiomegaly - physiopathology
Echocardiography
Essential hypertension
Humans
Hypertension - complications
Middle Aged
Norepinephrine
Plasma renin activity
Renin-Angiotensin System
Stroke Volume
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Summary:We attempted to clarify the pathogenesis of asymmetric ventricular hypertrophy in hypertensive patients, especially regarding sympathetic nervous system and renin-angiotensin system. Subjects were divided in 3 groups by echocardiographic findings; 1) 15 patients with non-hypertrophy (NH), 2) 14 patients with symmetric hypertrophy (SH), and 3) 10 patients with asymmetric hypertrophy (ASH). Subjects with ASH showed following features. Age (53.7±1.6yr) was older than NH (43.7±1.4yr) but not different from SH (49.7±2.3yr). Mean arterial pressure (119.0±3.9mmHg) was higher than NH (107.5±1.4mmHg) but not different from SH (122.4±2.8mmHg). End-diastolic and end-systolic dimensions were smaller and ejection fraction was larger than those of NH and SH. Cardiac index (3.90±0.37L/min/M2) was largest among 3 groups. UNE (19.5±3.5μg/day) was lower than SH (31.2±2.5μg/day). PRA (0.44±0.16ng/ml/h) was lower than SH (1.53±0.20ng/ml/h) and NH (1.62±0.28ng/ml/h). Ejection fraction was correlated with UNE (r=0.835) and PRA (r=0.736). We suggest that the heart of hypertensives with ASH is in hyperdynamic state due to the hyperresponsiveness to sympathetic stimuli, although they have a decrease of sympathetic nervous activity, and the renin-volume axis may have no important role on the pathogenesis of ASH.
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content type line 23
ISSN:0021-4868
1348-673X
DOI:10.1536/ihj.23.181