Reduction of adrenochrome by rat liver and brain DT-diaphorase

Liver and brain exhibit DT-diaphorase activity with adrenochrome as a substrate; the latter is an o-quinone derived from the autoxidation of adrenaline exhibiting neurotoxic and cardiotoxic properties. The reaction is strongly inhibited by dicoumarol, a classical inhibitor of DT-diaphorase. DT-diaph...

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Bibliographic Details
Published inFree radical research communications Vol. 8; no. 4-6; p. 295
Main Authors Bindoli, A, Rigobello, M P, Galzigna, L
Format Journal Article
LanguageEnglish
Published Switzerland 1990
Subjects
Adrenochrome - metabolism
Animals
Brain - enzymology
Brain - metabolism
Cytosol - enzymology
Cytosol - metabolism
In Vitro Techniques
Liver - enzymology
Liver - metabolism
NAD(P)H Dehydrogenase (Quinone)
NADP - metabolism
Oxidation-Reduction
Oxygen Consumption
Quinone Reductases - metabolism
Quinones - metabolism
Rats
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Summary:Liver and brain exhibit DT-diaphorase activity with adrenochrome as a substrate; the latter is an o-quinone derived from the autoxidation of adrenaline exhibiting neurotoxic and cardiotoxic properties. The reaction is strongly inhibited by dicoumarol, a classical inhibitor of DT-diaphorase. DT-diaphorase-reduced adrenochrome undergoes autoxidation as shown by the oxygen uptake occurring during the reaction. It is proposed that, physiologically, DT-diaphorase might exert a protective role by maintaining adrenochrome in its reduced, non-toxic form.
ISSN:8755-0199
DOI:10.3109/10715769009053362