Haemostasis in neurosurgery: What is the evidence for gelatin-thrombin matrix sealant?

Abstract Strict intra-operative haemostasis is essential in the practice of neurosurgery. Over the last century, haemostatic methods have advanced significantly and the modern surgeon is now faced with an array of haemostatic agents, each with subtly different qualities and proven in different conte...

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Bibliographic Details
Published inJournal of clinical neuroscience Vol. 20; no. 3; pp. 349 - 356
Main Authors Yao, Henry H.I, Hong, Matthew K.H, Drummond, Katharine J
Format Journal Article
LanguageEnglish
Published Scotland Elsevier Ltd 01.03.2013
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Summary:Abstract Strict intra-operative haemostasis is essential in the practice of neurosurgery. Over the last century, haemostatic methods have advanced significantly and the modern surgeon is now faced with an array of haemostatic agents, each with subtly different qualities and proven in different contexts with various levels of evidence. The popularity of endoscopic and laparoscopic procedures in other surgical specialties has encouraged the introduction of novel agents to achieve haemostasis where conventional methods have proven difficult. These agents are beginning to find a role in routine use for surgery in both the elective and emergent settings. This article reviews the mechanisms of different haemostasis methods and the current evidence for their use in neurosurgery, with a focus on the more recently introduced gelatin-thrombin matrix sealant (Floseal® [Baxter, Hayward, CA, USA]).
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ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2012.09.005