Impaired Skin Barrier Function in Mice with Colon Carcinoma Induced by Azoxymethane and Dextran Sodium Sulfate

• Published in: Biological & pharmaceutical bulletin Vol. 38; no. 6; pp. 947 - 950
• Main Authors: Yokoyama, Satoshi, Hiramoto, Keiichi, Koyama, Mayu, Ooi, Kazuya
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.06.2015; Japan Science and Technology Agency
• Subjects: Animals; Azoxymethane; Cell Membrane Permeability; Collagen Type I - metabolism; Colon - drug effects; Colon - pathology; colon cancer; Colonic Neoplasms - blood; Colonic Neoplasms - chemically induced; Colonic Neoplasms - complications; Colonic Neoplasms - pathology; dextran sodium sulfate; Dextran Sulfate; Male; Mice, Hairless; Nitrogen Dioxide - blood; Nitrogen Oxides - blood; Skin - metabolism; Skin - pathology; skin barrier function; type I collagen; Water - metabolism
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.b15-00208

We have previously reported that impaired skin barrier function was induced by small intestinal injury in mice. Therefore, we postulated that other intestinal diseases might also influence skin barrier function. In this study, we evaluated the skin barrier function of hairless mice with colon carcinoma that was induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). In mice treated with these drugs, we observed elevated transepidermal water loss and reduced skin hydration levels, compared to those in the control mice. In addition, plasma nitrogen di/trioxide (NO2−/NO3−) levels were significantly elevated, and expression of type I collagen was significantly reduced in the treated mice, compared to those in control. These results suggest that impaired skin barrier function occurs in mice when colon carcinoma is present.