Clostridium difficile Infections in an Emergency Surgical Unit from North-East Romania

• Published in: Medicina (Kaunas, Lithuania) Vol. 59; no. 5; p. 830
• Main Authors: Ciuntu, Bogdan Mihnea, Balan, Gheorghe G, Buna-Arvinte, Mihaela, Abdulan, Irina Mihaela, Papancea, Adelina, Toma, Ștefan Lucian, Veliceasa, Bogdan, Bădulescu, Oana Viola, Ghiga, Gabriela, Fătu, Ana Maria, Vascu, Mihai Bogdan, Moldovanu, Antonia, Vintilă, Dan, Vasilescu, Alin Mihai
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.04.2023; MDPI
• Subjects: Antibiotics; Antibodies; Antigens; Clostridioides difficile; Clostridium difficile infection; Clostridium Infections - diagnosis; Clostridium Infections - epidemiology; Clostridium Infections - surgery; colitis; Colitis - complications; Colitis - surgery; Enterocolitis, Pseudomembranous - complications; Enterocolitis, Pseudomembranous - epidemiology; Enterocolitis, Pseudomembranous - surgery; Hospitals; Humans; Inflammatory bowel disease; Laboratories; Medical research; Mortality; Nosocomial infections; Ostomy; Prospective Studies; Retrospective Studies; Romania - epidemiology; Surgery; surgical intervention; Toxins; Romania; mortality; colitis; Clostridium difficile infection; surgical intervention
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina59050830

: Colitis with is an important health problem that occurs with an intensity that varies between mild and severe. Surgical interventions are required only in fulminant forms. There is little evidence regarding the best surgical intervention in these cases. : Patients with infection were identified from the two surgery clinics from the 'Saint Spiridon' Emergency Hospital Iași, Romania. Data regarding the presentation, indication for surgery, antibiotic therapy, type of toxins, and post-operative outcomes were collected over a 3-year period. : From a total of 12,432 patients admitted for emergency or elective surgery, 140 (1.12%) were diagnosed with infection. The mortality rate was 14% (20 cases). Non-survivors had higher rates of lower-limb amputations, bowel resections, hepatectomy, and splenectomy. Additional surgery was necessary in 2.8% of cases because of the complications of colitis. In three cases, terminal colostomy was performed and as well as one case with subtotal colectomy with ileostomy. All patients who required the second surgery died within the 30-day mortality period. : In our prospective study, the incidence was increased both in cases of patients with interventions on the colon and in those requiring limb amputations. Surgical interventions are rarely required in patients with colitis.