X-ray imaging of newly-developed gadolinium compound/silica core–shell particles
A preparation method for gadolinium compound (Gd) nanoparticles coated with silica (Gd/SiO 2 ) is proposed. Gd nanoparticles were prepared with a homogeneous precipitation method at 80 °C using 1.0 × 10 −3 M Gd(NO 3 ) 3 and 0.5 M urea in the presence of 1.0 g/L stabilizer. Among stabilizers examined...
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Published in | Journal of sol-gel science and technology Vol. 59; no. 3; pp. 650 - 657 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Springer US
01.09.2011
Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | A preparation method for gadolinium compound (Gd) nanoparticles coated with silica (Gd/SiO
2
) is proposed. Gd nanoparticles were prepared with a homogeneous precipitation method at 80 °C using 1.0 × 10
−3
M Gd(NO
3
)
3
and 0.5 M urea in the presence of 1.0 g/L stabilizer. Among stabilizers examined. Sodium n-dodecyl sulfate (SDS) was suitable as the stabilizer for preparing small Gd nanoparticles, and consequently Gd nanoparticles with a size of 46.2 ± 12.4 nm were prepared using the SDS. Silica-coating of the Gd nanoparticles was performed by a Stöber method at room temperature using 0.013 M TEOS and 2.0 × 10
−3
M NaOH in water/1-propanol solution in the presence of 1.0 × 10
−3
M Gd nanoparticles, which resulted in production of Gd/SiO
2
particles with an average size of 64.2 ± 14.4 nm. The Gd/SiO
2
particles were surface-modified with 3-aminopropyltrimethoxysilane and succinic anhydride. It was confirmed by measurement of electrophretic light scattering that amino group or carboxyl group was introduced onto the Gd/SiO
2
particles. The gadolinium concentration of 1.0 × 10
−3
M in the as-prepared colloid solution was increased up to a gadolinium concentration of 0.4 M by centrifugation. The core–shell structure of Gd/SiO
2
particles was undamaged, and the colloid solution was still colloidally stable, even after the concentrating process. The concentrated Gd/SiO
2
colloid solution showed an X-ray image with contrast as high as a commercial Gd complex contrast agent. Internal organs in a mouse could be imaged injecting the concentrated colloid solution into it. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0928-0707 1573-4846 |
DOI: | 10.1007/s10971-011-2540-6 |