Circadian rhythm, sleep pattern, and metabolic consequences: an overview on cardiovascular risk factors

• Published in: Hormone molecular biology and clinical investigation Vol. 18; no. 1; pp. 47 - 52
• Main Authors: Machado, Roberta Marcondes, Koike, Marcia Kiyomi
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.04.2014; Walter de Gruyter GmbH
• Subjects: Biological clocks; Cardiovascular disease; Cardiovascular Diseases - metabolism; circadian cycle; Circadian rhythm; Circadian Rhythm - physiology; clock metabolism; Humans; Inflammation - metabolism; Inflammation - physiopathology; Metabolism; Older people; Risk Factors; Sleep; Sleep - physiology; Sleep Wake Disorders - metabolism; Sleep Wake Disorders - physiopathology; suprachiasmatic nuclei; Suprachiasmatic Nucleus - metabolism
• ISSN: 1868-1883; 1868-1891
• DOI: 10.1515/hmbci-2013-0057

Sleep duration is a risk factor for cardiovascular disease. Alteration in sleep pattern can induce the loss of circadian rhythmicity. Chronically, this desynchronization between endogenous rhythm and behavioral cycles can lead to an adverse metabolic profile, a proinflammatory condition and can increase the risk of cardiovascular disease. The circadian cycle can vary due to environmental cues. The circadian pacemaker is located in the suprachiasmatic nuclei; this central clock coordinates the circadian rhythm in the central nervous system and peripheral tissues. The mechanisms involved in sleep disturbance, circadian misalignment and adverse metabolic effects have yet to be fully elucidated. This review looks over the association among sleep alteration, circadian rhythm and the development of risk factors implicated in cardiovascular disease.