Inhibition of experimental choroidal neovascularization by an anti-growth agent inhibiting vascular endothelial development

• Published in: Japanese journal of ophthalmology Vol. 47; no. 5; p. 454
• Main Authors: Matsuo, Yoko, Li, Yutao, Taniguchi, Hiroyasu, Motoda, Masanori, Amemiya, Tsugio
• Format: Journal Article
• Language: English
• Published: Japan 01.09.2003
• Subjects: Angiogenesis Inhibitors - pharmacology; Animals; Capillaries - ultrastructure; Choroidal Neovascularization - etiology; Choroidal Neovascularization - prevention & control; Corrosion Casting; Drug Administration Schedule; Endothelium, Vascular - drug effects; Endothelium, Vascular - growth & development; Laser Coagulation; Microscopy, Electron, Scanning; Rats; Rats, Inbred BN; Spiro Compounds - administration & dosage; Spiro Compounds - pharmacology
• ISSN: 0021-5155
• DOI: 10.1016/S0021-5155(03)00136-9

To determine whether FR118487, a recently developed angiogenesis inhibitor, affects experimental choroidal neovascularization (CNV) induced by laser photocoagulation in pigmented rats. Focal laser photocoagulation (argon green 50 mW, 0.04 seconds, 200 microm) was applied to the retinochoroid of normal Brown Norway rats. Systemic administration of FR118487 (1.0 mg/kg body weight per day) with a mini-osmotic pump implanted in the subcutaneous tissue of the neck was started just after laser photocoagulation and continued for 2 weeks. Choroidal vascular casts were made 2 weeks after laser photocoagulation and were examined with a scanning electron microscope. CNV formation was divided into three grades and evaluated. Laser-induced CNV formation was significantly less in rats given FR118487 than in control rats. CNVs in rats treated with FR118487 were less well developed than in the controls. FR118487 inhibits the development of experimental CNV induced by photocoagulation in pigmented rats.