Coronary flow velocity reserve does not correlate with TIMI frame count in patients undergoing non-emergency percutaneous coronary intervention

• Published in: Journal of the American College of Cardiology Vol. 44; no. 4; pp. 778 - 782
• Main Authors: Chugh, Sanjay K., Koppel, Jennifer, Scott, Mark, Shewchuk, Lana, Goodhart, David, Bonan, Raoul, Tardif, Jean-Claude, Worthley, Stephen G., DiMario, Carlo, Curtis, Michael J., Meredith, Ian T., Anderson, Todd J.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 18.08.2004; Elsevier Science; Elsevier Limited
• Subjects: Adenosine; Angioplasty, Balloon, Coronary; Biological and medical sciences; Blood Flow Velocity; Cardiology; Cardiology. Vascular system; Collateral Circulation; Coronary Circulation; Coronary vessels; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiology; Diseases of the cardiovascular system; Female; Heart attacks; Humans; Male; Medical sciences; Middle Aged; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Ultrasonography; Veins & arteries; CFVR; CTFC; MLD; TIMI; APV; PCI; LV; MI; DESTINI; Human; Reserve; Regional blood flow; Angioplasty; Coronary artery; Instrumentation therapy; Circulatory velocity; Flow velocity; Emergency
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2004.05.048

The purpose of this research was to compare the Thrombolysis In Myocardial Infarction (TIMI) frame count (CTFC) with coronary flow velocity reserve (CFVR) in patients undergoing percutaneous coronary intervention (PCI). The relationship between CTFC and CFVR has not been adequately assessed in patients with coronary artery disease. We studied 62 patients who underwent successful non-emergent PCI. All patients had Doppler evaluation of CFVR, CTFC, and quantitative coronary angiography. In an additional 17 patients, a frame count reserve was calculated as baseline CTFC/CTFC at peak hyperemia, induced by intracoronary adenosine after PCI. The CTFC decreased from 27 ± 13 to 18 ± 8, and CFVR increased from 1.5 ± 0.4 to 2.6 ± 0.7 (both p < 0.0001). The pre-PCI CTFC and the CFVR were closely related to minimal lumen diameter (p < 0.0001). After PCI, there was no correlation between CFVR and CTFC. In addition, no relationship was observed between CFVR and the frame count reserve. There was no significant correlation between CFVR and CTFC in patients undergoing coronary intervention. The relative utility of these measures in predicting outcomes in this setting requires further evaluation, but CTFC (or frame count reserve) does not appear to be an adequate surrogate measure of Doppler-derived CFVR.