Immunoregulatory properties of mast cell-derived exosomes

Transmission of information from mast cells to neighboring or distant cells must be established continuously in order to ensure homeostasis or to initiate immune and inflammatory responses. Owing to their strategic location in peripheral tissues and their prompt response to various stimuli, mast cel...

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Published inMolecular Immunology Vol. 38; no. 16; pp. 1359 - 1362
Main Authors Dimitris, Skokos, Hany, Goubran-Botros, Michèle, Roa, Salah, Mécheri
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2002
Subjects
Animals
Cell Communication
Exocytosis
Exosomes
Immune response
Lysosomes - chemistry
Mast cells
Mast Cells - chemistry
Mast Cells - immunology
Secretory Vesicles - chemistry
Secretory Vesicles - physiology
Exosomes
Mast cells
Immune response
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Summary:Transmission of information from mast cells to neighboring or distant cells must be established continuously in order to ensure homeostasis or to initiate immune and inflammatory responses. Owing to their strategic location in peripheral tissues and their prompt response to various stimuli, mast cells can be considered as the cell prototype to fulfill such a sentinel function. There are several ways for mast cells to communicate with other cells including cell–cell interactions via membrane-associated receptors, cytokines and other soluble mediators, and a newly described messenger which consists of membrane vesicles called exosomes carrying a number of immunoregulatory molecules.
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ISSN:0161-5890
1872-9142
DOI:10.1016/S0161-5890(02)00088-3