Effects of aspirin (325 mg/day) on serum high-sensitivity C-reactive protein, cytokines, and adhesion molecules in healthy volunteers
This is a randomized, prospective, crossover study designed to test whether aspirin (325 mg/day) possesses any significant anti-inflammatory effect. Levels of-high sensitivity Greactive protein, interleukin-6, soluble intracellular adhesion molecules, and CDllb/CD18 expression on monoctyes were meas...
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| Published in | The American journal of cardiology Vol. 92; no. 2; pp. 236 - 239 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
15.07.2003
Elsevier Elsevier Limited |
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| Online Access | Get full text |
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| Abstract | This is a randomized, prospective, crossover study designed to test whether aspirin (325 mg/day) possesses any significant anti-inflammatory effect. Levels of-high sensitivity Greactive protein, interleukin-6, soluble intracellular adhesion molecules, and CDllb/CD18 expression on monoctyes were measured at different time intervals in 37 healthy volunteers and were not reduced with aspirin therapy. |
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| AbstractList | This is a randomized, prospective, crossover study designed to test whether aspirin (325 mg/day) possesses any significant anti-inflammatory effect. Levels of-high sensitivity Greactive protein, interleukin-6, soluble intracellular adhesion molecules, and CDllb/CD18 expression on monoctyes were measured at different time intervals in 37 healthy volunteers and were not reduced with aspirin therapy. |
| Author | Kassab, Roland Germanos, Mirna Aboujaoudé, Simon Klayme, Samira Azar, Rabih R. Naman, Roger Tawm, Samer |
| Author_xml | – sequence: 1 givenname: Rabih R. surname: Azar fullname: Azar, Rabih R. email: razar@usj.edu.lb organization: Division of Cardiology, Hotel-Dieu de France Hospital, , Beirut, Lebanon – sequence: 2 givenname: Samira surname: Klayme fullname: Klayme, Samira organization: Division of Cardiology, Hotel-Dieu de France Hospital, , Beirut, Lebanon – sequence: 3 givenname: Mirna surname: Germanos fullname: Germanos, Mirna organization: Division of Cardiology, Hotel-Dieu de France Hospital, , Beirut, Lebanon – sequence: 4 givenname: Roland surname: Kassab fullname: Kassab, Roland organization: Division of Cardiology, Hotel-Dieu de France Hospital, , Beirut, Lebanon – sequence: 5 givenname: Samer surname: Tawm fullname: Tawm, Samer organization: Division of Cardiology, Hotel-Dieu de France Hospital, , Beirut, Lebanon – sequence: 6 givenname: Simon surname: Aboujaoudé fullname: Aboujaoudé, Simon organization: Division of Cardiology, Hotel-Dieu de France Hospital, , Beirut, Lebanon – sequence: 7 givenname: Roger surname: Naman fullname: Naman, Roger organization: Division of Cardiology, Hotel-Dieu de France Hospital, , Beirut, Lebanon |
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| Cites_doi | 10.1056/NEJM200003233421202 10.1056/NEJM199704033361401 10.1161/01.CIR.101.15.1767 10.1023/A:1018644212794 10.1016/S0735-1097(01)01130-5 10.1056/NEJM199408183310701 10.1161/01.CIR.94.5.874 10.1161/01.CIR.103.15.1933 10.1016/S0140-6736(97)09032-6 10.1016/S0735-1097(01)01289-X 10.1161/01.CIR.100.8.793 |
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| Keywords | Human Intercellular adhesion molecule 1 Low dose Cytokine Biological marker Exploration Inflammation Acetylsalicylic acid Interleukin 6 High sensitivity Adhesin Mechanism of action C reactive protein |
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| References | Ridker, Hennekens, Buring, Rifai (BIB2) 2000; 342 Ridker, Hennekens, Roitman-Johnson, Stampfer, Allen (BIB4) 1998; 351 Liuzzo, Biasucci, Gallimore, Grillo, Rebuzzi, Pepys, Maseri (BIB5) 1994; 331 Ridker, Cushman, Stampfer, Tracy, Hennekens (BIB1) 1997; 336 Feng, Tracy, Lipinska, Murillo, McKenna, Tofler (BIB7) 2000; 9 Biasucci, Bitelli, Liuzzo, Altamura, Caligiuri, Monaco, Rebuzzi, Ciliberto, Maseri (BIB9) 1996; 94 Kennon, Price, Mills, Ranjadayalan, Cooper, Clarke, Timmis (BIB10) 2001; 37 Feldman, Jialal, Devaraj, Cryer (BIB6) 2001; 37 Ikonomidis, Andreotti, Economou, Stefanadis, Toutouzas, Nihoy-annopoulos (BIB8) 1999; 100 Jialal, Stein, Balis, Grundy, Adams-Huet, Devaraj (BIB11) 2001; 103 Ridker, Rifai, Stampfer, Nennekens (BIB3) 2000; 101 Feng (10.1016/S0002-9149(03)00549-6_BIB7) 2000; 9 Ridker (10.1016/S0002-9149(03)00549-6_BIB4) 1998; 351 Feldman (10.1016/S0002-9149(03)00549-6_BIB6) 2001; 37 Biasucci (10.1016/S0002-9149(03)00549-6_BIB9) 1996; 94 Ridker (10.1016/S0002-9149(03)00549-6_BIB1) 1997; 336 Ridker (10.1016/S0002-9149(03)00549-6_BIB3) 2000; 101 Liuzzo (10.1016/S0002-9149(03)00549-6_BIB5) 1994; 331 Jialal (10.1016/S0002-9149(03)00549-6_BIB11) 2001; 103 Ridker (10.1016/S0002-9149(03)00549-6_BIB2) 2000; 342 Ikonomidis (10.1016/S0002-9149(03)00549-6_BIB8) 1999; 100 Kennon (10.1016/S0002-9149(03)00549-6_BIB10) 2001; 37 |
| References_xml | – volume: 100 start-page: 793 year: 1999 end-page: 798 ident: BIB8 article-title: Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin publication-title: Circulation contributor: fullname: Nihoy-annopoulos – volume: 331 start-page: 417 year: 1994 end-page: 424 ident: BIB5 article-title: The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina publication-title: N Engl J Med contributor: fullname: Maseri – volume: 103 start-page: 1933 year: 2001 end-page: 1935 ident: BIB11 article-title: Effect of hydroxymethylglutary coenzyme A reductase inhibitor therapy on high sensitive C-reactive protein levels publication-title: Circulation contributor: fullname: Devaraj – volume: 9 start-page: 37 year: 2000 end-page: 41 ident: BIB7 article-title: Effect of short-term aspirin use on C-reactive protein publication-title: J Thromb Thrombolysis contributor: fullname: Tofler – volume: 351 start-page: 88 year: 1998 end-page: 92 ident: BIB4 article-title: Plasma concentration of soluble intercellular adhesion molecule 1 and risk of future myocardial infarction in apparently healthy men publication-title: Lancet contributor: fullname: Allen – volume: 94 start-page: 874 year: 1996 end-page: 877 ident: BIB9 article-title: Elevated levels of interleukin-6 in unstable angina publication-title: Circulation contributor: fullname: Maseri – volume: 37 start-page: 1266 year: 2001 end-page: 1270 ident: BIB10 article-title: The effect of aspirin on C-reactive protein as a marker of risk in unstable angina publication-title: J Am Coll Cardiol contributor: fullname: Timmis – volume: 342 start-page: 836 year: 2000 end-page: 843 ident: BIB2 article-title: C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women publication-title: N Engl J Med contributor: fullname: Rifai – volume: 37 start-page: 2036 year: 2001 end-page: 2041 ident: BIB6 article-title: Effects of low-dose aspirin on serum C-reactive protein and thromboxane B publication-title: J Am Coll Cardiol contributor: fullname: Cryer – volume: 336 start-page: 973 year: 1997 end-page: 979 ident: BIB1 article-title: Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men publication-title: N Engl J Med contributor: fullname: Hennekens – volume: 101 start-page: 1767 year: 2000 end-page: 1772 ident: BIB3 article-title: Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men publication-title: Circulation contributor: fullname: Nennekens – volume: 342 start-page: 836 year: 2000 ident: 10.1016/S0002-9149(03)00549-6_BIB2 article-title: C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women publication-title: N Engl J Med doi: 10.1056/NEJM200003233421202 contributor: fullname: Ridker – volume: 336 start-page: 973 year: 1997 ident: 10.1016/S0002-9149(03)00549-6_BIB1 article-title: Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men publication-title: N Engl J Med doi: 10.1056/NEJM199704033361401 contributor: fullname: Ridker – volume: 101 start-page: 1767 year: 2000 ident: 10.1016/S0002-9149(03)00549-6_BIB3 article-title: Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men publication-title: Circulation doi: 10.1161/01.CIR.101.15.1767 contributor: fullname: Ridker – volume: 9 start-page: 37 year: 2000 ident: 10.1016/S0002-9149(03)00549-6_BIB7 article-title: Effect of short-term aspirin use on C-reactive protein publication-title: J Thromb Thrombolysis doi: 10.1023/A:1018644212794 contributor: fullname: Feng – volume: 37 start-page: 1266 year: 2001 ident: 10.1016/S0002-9149(03)00549-6_BIB10 article-title: The effect of aspirin on C-reactive protein as a marker of risk in unstable angina publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(01)01130-5 contributor: fullname: Kennon – volume: 331 start-page: 417 year: 1994 ident: 10.1016/S0002-9149(03)00549-6_BIB5 article-title: The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina publication-title: N Engl J Med doi: 10.1056/NEJM199408183310701 contributor: fullname: Liuzzo – volume: 94 start-page: 874 year: 1996 ident: 10.1016/S0002-9149(03)00549-6_BIB9 article-title: Elevated levels of interleukin-6 in unstable angina publication-title: Circulation doi: 10.1161/01.CIR.94.5.874 contributor: fullname: Biasucci – volume: 103 start-page: 1933 year: 2001 ident: 10.1016/S0002-9149(03)00549-6_BIB11 article-title: Effect of hydroxymethylglutary coenzyme A reductase inhibitor therapy on high sensitive C-reactive protein levels publication-title: Circulation doi: 10.1161/01.CIR.103.15.1933 contributor: fullname: Jialal – volume: 351 start-page: 88 year: 1998 ident: 10.1016/S0002-9149(03)00549-6_BIB4 article-title: Plasma concentration of soluble intercellular adhesion molecule 1 and risk of future myocardial infarction in apparently healthy men publication-title: Lancet doi: 10.1016/S0140-6736(97)09032-6 contributor: fullname: Ridker – volume: 37 start-page: 2036 year: 2001 ident: 10.1016/S0002-9149(03)00549-6_BIB6 article-title: Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(01)01289-X contributor: fullname: Feldman – volume: 100 start-page: 793 year: 1999 ident: 10.1016/S0002-9149(03)00549-6_BIB8 article-title: Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin publication-title: Circulation doi: 10.1161/01.CIR.100.8.793 contributor: fullname: Ikonomidis |
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| Title | Effects of aspirin (325 mg/day) on serum high-sensitivity C-reactive protein, cytokines, and adhesion molecules in healthy volunteers |
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