Effects of aspirin (325 mg/day) on serum high-sensitivity C-reactive protein, cytokines, and adhesion molecules in healthy volunteers

This is a randomized, prospective, crossover study designed to test whether aspirin (325 mg/day) possesses any significant anti-inflammatory effect. Levels of-high sensitivity Greactive protein, interleukin-6, soluble intracellular adhesion molecules, and CDllb/CD18 expression on monoctyes were meas...

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Bibliographic Details
Published inThe American journal of cardiology Vol. 92; no. 2; pp. 236 - 239
Main Authors Azar, Rabih R., Klayme, Samira, Germanos, Mirna, Kassab, Roland, Tawm, Samer, Aboujaoudé, Simon, Naman, Roger
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.07.2003
Elsevier
Elsevier Limited
Subjects
Adult
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin
Aspirin - administration & dosage
Aspirin - pharmacology
Aspirin - therapeutic use
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
C-Reactive Protein - analysis
C-Reactive Protein - drug effects
Cell Adhesion Molecules - blood
Cell Adhesion Molecules - drug effects
Coronary Artery Disease - blood
Coronary Artery Disease - prevention & control
Cross-Over Studies
Dose-Response Relationship, Drug
Effects
Female
Health
Humans
Interleukin-6 - blood
Macrophage-1 Antigen - blood
Macrophage-1 Antigen - drug effects
Male
Medical sciences
Middle Aged
Molecules
Pharmacology. Drug treatments
Prospective Studies
Proteins
Reference Values
Human
Intercellular adhesion molecule 1
Low dose
Cytokine
Biological marker
Exploration
Inflammation
Acetylsalicylic acid
Interleukin 6
High sensitivity
Adhesin
Mechanism of action
C reactive protein
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Summary:This is a randomized, prospective, crossover study designed to test whether aspirin (325 mg/day) possesses any significant anti-inflammatory effect. Levels of-high sensitivity Greactive protein, interleukin-6, soluble intracellular adhesion molecules, and CDllb/CD18 expression on monoctyes were measured at different time intervals in 37 healthy volunteers and were not reduced with aspirin therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(03)00549-6