Primary large B-cell lymphoma of the fourth ventricle

• Published in: Journal of clinical neuroscience Vol. 21; no. 1; pp. 180 - 183
• Main Authors: Liao, Chih-Hsiang, Lin, Shih-Chieh, Hung, Sheng-Che, Hsu, Sanford P.C, Ho, Donald Ming-Tak, Shih, Yang-Hsin
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.01.2014
• Subjects: Aged; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Central nervous system; Diffuse large-cell lymphoma; Diffusion Magnetic Resonance Imaging; Fourth Ventricle - pathology; Fourth Ventricle - surgery; Fourth ventricle tumor; Humans; Immunocompetence; Lymphoma, Large B-Cell, Diffuse - pathology; Lymphoma, Large B-Cell, Diffuse - surgery; Male; Neurology; Non-Hodgkin’s lymphoma; Non-Hodgkin’s lymphoma; Diffuse large-cell lymphoma; Fourth ventricle tumor; Immunocompetence; Central nervous system
• ISSN: 0967-5868; 1532-2653
• DOI: 10.1016/j.jocn.2013.02.036

Abstract We present a patient with an isolated primary central nervous system lymphoma (PCNSL) of the fourth ventricle. A 77-year-old man had a 1 week history of intermittent vertigo, nausea, vomiting, and progressively unsteady gait. CT scans of the brain showed a fourth ventricle tumor. MRI revealed a 2.5 cm dumbbell-shaped avidly-enhancing tumor in the fourth ventricle. Metastasis or high-grade glioma was suspected. The neuropathological findings were compatible with a diffuse large B-cell lymphoma. A slit lamp examination, bone marrow biopsy, and imaging studies for extracranial lesions were unremarkable. We suggest that PCNSL be listed in the differential diagnosis of fourth ventricle tumors with well-circumscribed margins and homogenous contrast enhancement.