Fibroblast Growth Factor-2 Stimulates Hyaluronan Production by Human Dental Pulp Cells

Hyaluronan (HA), is a high molecular mass extracellular matrix constituting connective tissue and plays a critical role in not only homeostasis but also inflammatory and wound-healing responses. In this study, we investigated the effect of fibroblast growth factor (FGF)-2 on the production of HA by...

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Published inJournal of endodontics Vol. 31; no. 11; pp. 805 - 808
Main Authors Shimabukuro, Yoshio, Ueda, Maki, Ichikawa, Tomoo, Terashi, Yoshimitsu, Yamada, Satoru, Kusumoto, Yutaka, Takedachi, Masahide, Terakura, Mami, Kohya, Akira, Hashikawa, Tomoko, Murakami, Shinya
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2005
Subjects
Cells, Cultured
Dental Pulp - cytology
Dental Pulp - drug effects
Dental pulp cell
Dentistry
FGF-2
Fibroblast Growth Factor 2 - pharmacology
Glucuronosyltransferase - analysis
Glucuronosyltransferase - drug effects
Humans
hyaluronan
hyaluronan synthase
Hyaluronan Synthases
Hyaluronic Acid - analysis
Isoenzymes - analysis
Isoenzymes - drug effects
RNA, Messenger - analysis
FGF-2
hyaluronan synthase
Dental pulp cell
hyaluronan
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Summary:Hyaluronan (HA), is a high molecular mass extracellular matrix constituting connective tissue and plays a critical role in not only homeostasis but also inflammatory and wound-healing responses. In this study, we investigated the effect of fibroblast growth factor (FGF)-2 on the production of HA by human dental pulp cells (HDPC). An inhibition binding-protein assay showed that FGF-2 increased HA production by HDPC. In addition, expression of mRNA of hyaluronan synthase (HAS) 1 and HAS 2, both of which are related to the production of high molecular mass of HA, but not HAS 3, was enhanced in FGF-2-stimulated HDPC. These results provide new evidence for the involvement of FGF-2 in the regulation of HA production by HDPC possibly through HAS 1 and HAS 2.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0099-2399
1878-3554
DOI:10.1097/01.don.0000158242.44155.49