Bradykinin modulates the release of noradrenaline from vas deferens nerve terminals

To asses whether bradykinin influences the release of noradrenaline from the adrenergic varicosities of the vas deferens, tissues were loaded with 3H-noradrenaline. Upon electrical depolarization bradykinin increased in a concentration-dependent fashion, the overflow of tritium from the mouse or rat...

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Bibliographic Details
Published inLife sciences (1973) Vol. 48; no. 26; p. 2585
Main Authors Llona, I, Galleguillos, X, Belmar, J, Huidobro-Toro, J P
Format Journal Article
LanguageEnglish
Published Netherlands 1991
Subjects
Animals
Bradykinin - analysis
Bradykinin - physiology
Calcium - metabolism
Male
Mice
Norepinephrine - metabolism
Radioimmunoassay
Rats
Rats, Inbred Strains
Receptors, Adrenergic - metabolism
Vas Deferens - innervation
Vas Deferens - metabolism
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Summary:To asses whether bradykinin influences the release of noradrenaline from the adrenergic varicosities of the vas deferens, tissues were loaded with 3H-noradrenaline. Upon electrical depolarization bradykinin increased in a concentration-dependent fashion, the overflow of tritium from the mouse or rat vas deferens. The 3H-overflow is dependent on the external Ca2+concentration suggesting neuronal release of 3H-noradrenaline. The present results add evidence to the hypothesis that bradykinin modulates the release of noradrenaline from peripheral sympathetic nerve terminals via the activation of a presynaptic mechanism.
ISSN:0024-3205
DOI:10.1016/0024-3205(91)90616-J