The potential of arabica coffee grounds nanoparticles as an active compound of pharmaceutical preparations

• Published in: IOP conference series. Earth and environmental science Vol. 425; no. 1; pp. 12034 - 12041
• Main Authors: Nurman, S, Yulia, R, Irmayanti, Noor, E, Sunarti, T C
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.01.2020
• Subjects: Alkanes; Ball milling; Carboxylic acids; Coffee; Fourier analysis; Fourier transforms; Functional groups; Infrared spectroscopy; Metabolites; Morphology; Nanoparticles; Particle size; pH effects; Pharmaceuticals; Phenols; Pilot projects; Polydispersity; Saponins; Scanning electron microscopy; Secondary metabolites; Solid wastes; Specialty products
• ISSN: 1755-1307; 1755-1315
• DOI: 10.1088/1755-1315/425/1/012034

Arabica coffee (Coffea arabica L.) grounds are kind of solid waste produced from filtering process containing many bioactive components and good for health. Nanoparticle technology can be used to produce nanoscale particles without separating the active compounds contained the rein. The aim of this study is to determine the potential of Arabica coffee grounds nanoparticles as active compounds to be used in pharmaceutical preparations. The research procedure was begun with collect the Arabica coffee grounds which was then processed into nanoparticles using the ball milling and ultrasonication technique. The nanoparticles were characterized using some techniques, namely particle size analysis using PSA (Particle Size Analyzer), phytochemical screening, total phenolics, pH, particle morphology using SEM (Scanning Electron Microscopy) and particle structure using FT-IR (Fourier Transform Infrared Spectroscopy). The results showed that Arabica coffee grounds nanoparticles has a particle size of 396.0 nm with a polydispersity index of 0.254, solubility of 70.680% and pH 5.33, the positive Arabica coffee grounds nanoparticles containing secondary metabolites of alkaloids, saponins and phenolics with total phenolics 1246.90 μgGAE/g. Morphology of Arabica coffee grounds nanoparticles was in irregular granules form with an asymmetrical size and has active functional groups such as OH, NH, CH alkane, C≡N, C=O carboxylic acid, -C=C-, CO, and CC. It can be concluded that Arabica coffee grounds nanoparticles were potentially can be used as active compounds in various pharmaceutical preparations.