Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts

High doses of chemotherapy agents can cause adverse effects. To address this issue, drug-loaded vesicles with minimum drug loss, guided by an external element for precise delivery, are desired. Combinational therapy of both a focused ultrasound-induced drug delivery method and membrane fusogenic lip...

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Published inMaterials Vol. 13; no. 5; p. 1099
Main Authors Kim, Daehyun, Han, Junhee, Park, So Yeon, Kim, Heegon, Park, Ji-Ho, Lee, Hak Jong
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 02.03.2020
MDPI AG
Subjects
cancer
liposome
ultrasound
cancer
liposome
ultrasound
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Summary:High doses of chemotherapy agents can cause adverse effects. To address this issue, drug-loaded vesicles with minimum drug loss, guided by an external element for precise delivery, are desired. Combinational therapy of both a focused ultrasound-induced drug delivery method and membrane fusogenic liposomes (MFLs) as drug delivery vehicles can satisfy such premises. In this study, we confirmed that the use of a small quantity of docetaxel-loaded membrane fusogenic liposomes (DTX-MFL) with focused ultrasound can induce better antitumor response in a xenograft mouse model compared to conventional docetaxel monotherapy and DTX-MFL only.
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These authors contributed equally to this work.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma13051099