Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation

An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity-oriented synthesis of Illicium natural products t...

Full description

Saved in:
Bibliographic Details
Published inBeilstein journal of organic chemistry Vol. 9; no. 1; pp. 1135 - 1140
Main Authors Trzoss, Lynnie, Xu, Jing, Lacoske, Michelle H, Theodorakis, Emmanuel A
Format Journal Article
LanguageEnglish
Published Germany Beilstein-Institut 12.06.2013
Subjects
Chemistry
Full Research Paper
natural products
neurodegenerative diseases
neurotrophic small molecule
organocatalysis
total synthesis
organocatalysis
natural products
neurodegenerative diseases
total synthesis
neurotrophic small molecule
Online AccessGet full text
ISSN1860-5397
1860-5397
DOI10.3762/bjoc.9.126

Cover

More Information
Summary:An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity-oriented synthesis of Illicium natural products that holds remarkable therapeutic potential for neurodegenerative diseases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.9.126