The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma

• Published in: Experimental and therapeutic medicine Vol. 5; no. 3; pp. 890 - 896
• Main Authors: LU, HONGSHENG, YANG, ZHAOHUI, ZHANG, HUI, GAN, MEIFU, ZHOU, TAO, WANG, SILING
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.03.2013; Spandidos Publications UK Ltd
• Subjects: Angiogenesis; Cancer; clear cell renal cell carcinoma; Clinical significance; Kidney cancer; matrix metalloproteinase 7; Medical prognosis; Metastasis; Multivariate analysis; Patients; prognosis; Rodents; Studies; tissue inhibitor of matrix metalloproteinases 2; tissue microarray; Tumors; matrix metalloproteinase 7; clear cell renal cell carcinoma; tissue inhibitor of matrix metalloproteinases 2; tissue microarray; prognosis
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2012.859

Renal cell carcinoma (RCC) is one of the most common malignant neoplasms in the urinary system, and has a high frequency of local invasion and distant metastasis. This study assessed the expression and clinical significance of matrix metalloproteinase 7 (MMP-7) and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in human clear cell renal cell carcinoma (CCRCC) by tissue microarray, immunohistochemistry and RT-PCR analysis. The expression of MMP-7 in CCRCC tissues was significantly higher compared with that in the control group (CG) and TIMP-2 expression in CCRCC, by contrast, was lower compared with that in the CG. The expression of MMP-7 and TIMP-2 in the CCRCC tissues was significantly correlated with the pathological grade and clinical stage. Log-rank analyses indicated that upregulation of MMP-7 and downregulation of TIMP-2 expression may occur during the progression of CCRCC, and Cox multivariate survival rate analysis demonstrated that there was also a positive correlation between the pathological grade, clinical stage, MMP-7 expression and survival rate. Thus, MMP-7 is an independent prognostic factor and MMP-7 and TIMP-2 may serve as useful molecular markers for evaluating prognosis in CCRCC patients.