Families of arsenic transporters

• Published in: Trends in Microbiology Vol. 7; no. 5; pp. 207 - 212
• Main Author: Rosen, Barry P.
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.1999
• Subjects: ABC transporter; Acr3p protein; Adenosine Triphosphatases - metabolism; ars operon; arsAB protein; Arsenate reductase; Arsenate Reductases; arsenic resistance; Arsenicals - metabolism; Arsenicals - pharmacology; Arsenite resistance; Arsenite Transporting ATPases; ATP-Binding Cassette Transporters - metabolism; ATPase; Bacteria - drug effects; Bacteria - enzymology; Bacteria - metabolism; Carrier protein; Carrier Proteins - metabolism; Drug Resistance, Microbial - physiology; Fungal Proteins - metabolism; Genes, Bacterial; Ion Pumps; Membrane Proteins - genetics; Membrane Proteins - metabolism; Membrane Transport Proteins; Metalloregulation; Multidrug Resistance-Associated Proteins; Multienzyme Complexes; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins; Vacuoles - metabolism; Microbiology; Arsenate reductase; ATPase; Genetics; Biochemistry; Arsenite resistance; ABC transporter; Metalloregulation; Carrier protein
• ISSN: 0966-842X; 1878-4380
• DOI: 10.1016/S0966-842X(99)01494-8

Bacterial arsenic resistance ( ars) operons encode an arsenite-efflux system that can be a secondary carrier protein (ArsB) or an anion-translocating ATPase (ArsAB). Yeasts extrude arsenite using Acr3p, a plasma membrane carrier protein, or sequester it in vacuoles as the glutathione conjugate using Ycf1p, an ABC transporter.